%0 Journal Article
%T 胃腺癌组织中LRIG1蛋白的表达及意义
%A 李红
%A 赵红岩
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.06.011
%X 摘要 目的 探讨富亮氨酸重复序列免疫球蛋白样结构域1（LRIG1）在人体胃腺癌组织中的表达及其与临床病理参数的关系。方法 采用免疫组织化学EnVision二步法检测LRIG1蛋白在116例胃腺癌及其相应癌旁正常胃组织中的表达情况，并分析其表达与临床病理参数的关系。结果 LRIG1在胃腺癌组织中的阳性表达率（63.8%，74/116）低于癌旁正常胃组织（81.9%，95/116），差异具有统计学意义（P<0.05）。LRIG1蛋白的表达与肿瘤的分化程度、浸润深度、淋巴结转移、远处转移及TNM分期密切相关（P<0.05），而与患者年龄、性别及肿瘤大小无关（P>0.05）。结论 LRIG1在胃腺癌组织中的表达较相应癌旁正常胃组织低，而且随着肿瘤恶性程度的增加LRIG1蛋白的表达逐渐降低，可能作为抑癌基因参与了胃腺癌的发生、发展
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%U http://www.zlfzyj.com/CN/abstract/abstract8773.shtml