子宫颈鳞状细胞癌组织中LncRNA HCG11和miR-590-3p的表达及其与预后的关系
DOI: 10.3971/j.issn.1000-8578.2018.17.0614
Keywords: A Meta-analysis,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Risk Factors of Lymph Node Metastasis in Early-stage Cervical Cancer Patients and Build of A Nomogram Prediction Model,Correlation of FoxO3 Gene with Clinicopathological Features and Prognosis of Bladder Cancer Patients,Correlation Between States of Hepatitis B Virus Infection, Levels of Hepatitis B Surface Antigens/Antibodies and Staging, Prognosis of Colon Cancer,Expression and Correlation of Id-1, MMP-9 and LMVD in Colorectal Adenocarcinoma Tissues,Relationship of Expression Difference of miR-658 and miR-492 with Pelvic Lymph Node Metastasis from Squamous Carcinoma of Cervix,Expression and Significance of LRIG1 Protein in Gastric Adenocarcinoma Tissues,Diagnostic Value of PET/CT for Metastatic Lymph Nodes in Cervical Cancer Patients: A Meta-analysis,Relationship of Tumor Location and Other Clinicopathological Features with Differentiated Thyroid Cancer with Lymph Node Metastasis,Diagnostic Value of MRI in Detection of Small Lymph Node Metastasis and Its Effects on Radiotherapy Target Volume Design in Cervical Cancer Patients,Relative Factors and Surgical Treatment of Neck Lymph Node Metastasis of cN0 Tongue Cancer,Comparative Analysis of Clinicopathological Changes in Esophageal Cancer Patients#br# with Ultra-long and Short-term Survival,Impact of Lymph Node Metastasis and Relevant Risk Factors on Survival of Patients#br# with Esophageal Carcinoma from High- and low-incidence Areas
Abstract:
摘要 目的 探讨LncRNA HCG11和miR-590-3p在子宫颈鳞状细胞癌组织及配对的癌旁组织中的表达情况，以及二者表达水平与患者临床资料和预后的相关性。方法 收集58例子宫颈鳞状细胞癌和配对的癌旁正常组织标本，运用qRT-PCR法检测58对子宫颈鳞状细胞癌组织及相应的癌旁组织中的LncRNA HCG11和miR-590-3p的表达，分析与宫颈鳞状细胞癌临床病理和预后的相关性，并评价其临床意义。结果 荧光定量PCR显示宫颈鳞状细胞癌组织中LncRNA HCG11的表达比癌旁组织明显下调（P<0.05），miR-590-3p的表达比癌旁组织明显上调（P<0.05）；二者在核酸表达水平上呈负相关（r=-0.642, P=0.000）。 LncRNA HCG11和miR-590-3p的表达均与宫颈癌淋巴结转移、组织大小及临床分期之间存在显著的相关性，且与预后相关（P<0.05）。Cox回归多因素分析发现LncRNA HCG11和miR-590-3p分别可作为宫颈鳞状细胞癌患者独立的预后因子。结论 LncRNA HCG11和miR-590-3p可作为宫颈鳞状细胞癌独立的预后标志物和潜在的治疗靶点，LncRNA HCG11可能通过调控miR-590-3p的表达量从而发挥抑癌基因的作用
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