%0 Journal Article
%T 子宫颈鳞状细胞癌组织中LncRNA HCG11和miR-590-3p的表达及其与预后的关系
%A 刘平
%A 陈晓杰
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0614
%X 摘要 目的 探讨LncRNA HCG11和miR-590-3p在子宫颈鳞状细胞癌组织及配对的癌旁组织中的表达情况，以及二者表达水平与患者临床资料和预后的相关性。方法 收集58例子宫颈鳞状细胞癌和配对的癌旁正常组织标本，运用qRT-PCR法检测58对子宫颈鳞状细胞癌组织及相应的癌旁组织中的LncRNA HCG11和miR-590-3p的表达，分析与宫颈鳞状细胞癌临床病理和预后的相关性，并评价其临床意义。结果 荧光定量PCR显示宫颈鳞状细胞癌组织中LncRNA HCG11的表达比癌旁组织明显下调（P<0.05），miR-590-3p的表达比癌旁组织明显上调（P<0.05）；二者在核酸表达水平上呈负相关（r=-0.642, P=0.000）。 LncRNA HCG11和miR-590-3p的表达均与宫颈癌淋巴结转移、组织大小及临床分期之间存在显著的相关性，且与预后相关（P<0.05）。Cox回归多因素分析发现LncRNA HCG11和miR-590-3p分别可作为宫颈鳞状细胞癌患者独立的预后因子。结论 LncRNA HCG11和miR-590-3p可作为宫颈鳞状细胞癌独立的预后标志物和潜在的治疗靶点，LncRNA HCG11可能通过调控miR-590-3p的表达量从而发挥抑癌基因的作用
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%U http://www.zlfzyj.com/CN/abstract/abstract9121.shtml