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- 2018
黑色素瘤抗原泛素连接酶的研究进展DOI: 10.3971/j.issn.1000-8578.2018.17.1400 Keywords: 黑色素瘤抗原基因,MAGE-RING连接酶复合体,泛素化修饰,泛素连接酶,Advances in Relationship Between Nedd4-like Family of E3 Ubiquitin Ligases and Cancer,Expression and Signifi cance of PIRH2 and P53 Proteins in Esophageal Squamous Cell#br# Carcinoma Tissues,Expression and Clinical Significance of MAGE-1,3,4 Gene in Human Colorectal Carcinoma Abstract: 摘要 黑色素瘤抗原（melanoma-associated antigen gene, MAGE）被视为一种肿瘤标志物和免疫治疗的热门对象。研究发现MAGE联合E3-RING泛素连接酶形成MAGE-RING连接酶复合体（MAGE-RING ligases, MRLs），成为泛素化的调控因子，从而调控连接酶的活性、底物的特异性和亚细胞定位。该文就MRLs的结构、活化机制和转录功能作一综述
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