%0 Journal Article %T 黑色素瘤抗原泛素连接酶的研究进展 %A 严峻 %A 文静 %A 李希圣 %A 莫立根 %J 肿瘤防治研究 %D 2018 %R 10.3971/j.issn.1000-8578.2018.17.1400 %X 摘要 黑色素瘤抗原(melanoma-associated antigen gene, MAGE)被视为一种肿瘤标志物和免疫治疗的热门对象。研究发现MAGE联合E3-RING泛素连接酶形成MAGE-RING连接酶复合体(MAGE-RING ligases, MRLs),成为泛素化的调控因子,从而调控连接酶的活性、底物的特异性和亚细胞定位。该文就MRLs的结构、活化机制和转录功能作一综述 %K 黑色素瘤抗原基因 %K MAGE-RING连接酶复合体 %K 泛素化修饰 %K 泛素连接酶 %K Advances in Relationship Between Nedd4-like Family of E3 Ubiquitin Ligases and Cancer %K Expression and Signifi cance of PIRH2 and P53 Proteins in Esophageal Squamous Cell#br# Carcinoma Tissues %K Expression and Clinical Significance of MAGE-1 %K 3 %K 4 Gene in Human Colorectal Carcinoma %U http://www.zlfzyj.com/CN/abstract/abstract9163.shtml