食管中段鳞癌组织中MALAT1的表达及其与预后的关系
DOI: 10.3971/j.issn.1000-8578.2015.12.012
Keywords: MALAT1,食管鳞状细胞癌,长链非编码RNA,Effect of Long Non-coding RNA LOC100294362 on Proliferation and Invasion of Breast Cancer Cells,Expression of EZH2 and H3K27me3 in Esophageal Squamous Cell Carcinoma and Their Significance,LncRNA Colorectal Neoplasia Differentially Expressed(CRNDE) Regulated Cell Proliferation and Migration in Glioma,Association Between Long Non-coding RNA and Cervical Cancer,Support Vector Machine Predicts Survival of Esophageal Squamous Cell Carcinoma Patients,Screening of Long Non-coding RNA in Colon Cancer by Bioinformatics,Expression of Specific Long Non-coding RNA in Nasopharyngeal Carcinoma and Related Significance,Progress on miRNAs in Esophageal Squamous Cell Carcinoma,Tumor Suppressor Roles of miR-100 in Esophageal Squamous Cell Carcinoma Cell Line Ec-109,Screening of Differential DNA Methylation Profile and Construction of Aberrant Methylation Panel in Esophageal Squamous Cell Carcinoma,Expression of Metastasis Suppressor Gene KiSS-1 in Esophageal Squamous Cancer and Its Clinical Significance,Clinical Characteristics of Promoter Hypermethylation of PTEN Gene in Esophageal Carcinoma Tissues,New Research of Long Noncoding RNA in Tumor,Expression and Signifi cance of PIRH2 and P53 Proteins in Esophageal Squamous Cell#br# Carcinoma Tissues,Expression and Bioinformatics Analysis of hsa-miR-133a in Cell Lines of Human#br# Esophageal Squamous Cell Carcinoma
Abstract:
摘要 目的 探讨MALAT1的表达是否可以作为食管中段鳞癌患者根治术后的预后指标。方法 应用qRT-PCR法检测77例接受食管癌根治术治疗的食管中段鳞癌患者肿瘤组织及对应癌旁组织中MALAT1的表达水平及其与临床病理特征和预后的关系。结果 与癌旁组织相比，食管癌组织中MALAT1表达水平明显增高（P<0.001）。MALAT1的表达与患者T分期呈正相关。Kaplan-Meier生存分析显示MALAT1高表达组患者的术后无疾病进展时间（DFS）和总生存时间（OS）显著缩短（P=0.04, P=0.038）。多因素回归分析显示MALAT1表达水平对DFS和OS的风险比（HR）为1.73（95%CI=0.92~3.23, P=0.09）和1.71（95%CI=0.93~3.12, P=0.08）。结论 MALAT1的表达水平可能是接受根治术治疗的食管中段鳞癌患者的一项预后预测指标
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