%0 Journal Article
%T 食管中段鳞癌组织中MALAT1的表达及其与预后的关系
%A 姜文静
%A 张伟杰
%A 曹新广
%A 赵瑞华
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.12.012
%X 摘要 目的 探讨MALAT1的表达是否可以作为食管中段鳞癌患者根治术后的预后指标。方法 应用qRT-PCR法检测77例接受食管癌根治术治疗的食管中段鳞癌患者肿瘤组织及对应癌旁组织中MALAT1的表达水平及其与临床病理特征和预后的关系。结果 与癌旁组织相比，食管癌组织中MALAT1表达水平明显增高（P<0.001）。MALAT1的表达与患者T分期呈正相关。Kaplan-Meier生存分析显示MALAT1高表达组患者的术后无疾病进展时间（DFS）和总生存时间（OS）显著缩短（P=0.04, P=0.038）。多因素回归分析显示MALAT1表达水平对DFS和OS的风险比（HR）为1.73（95%CI=0.92~3.23, P=0.09）和1.71（95%CI=0.93~3.12, P=0.08）。结论 MALAT1的表达水平可能是接受根治术治疗的食管中段鳞癌患者的一项预后预测指标
%K MALAT1
%K 食管鳞状细胞癌
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%U http://www.zlfzyj.com/CN/abstract/abstract8660.shtml