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- 2015
肿瘤治疗中Clostridium novyi-NT的研究DOI: 10.3971/j.issn.1000-8578.2015.01.018 Keywords: 肿瘤治疗,Clostridium novyi-NT,溶瘤细菌,Inhibition Effect of Ad-IL24 Combined with Low Dose of 5-Fu on Hepatocarcinoma Cells HepG2 and Its Mechanism,Review on Brain Metastases in HER2-positive Breast Cancer Patients,Therapeutic-effect of Different Dosage of rmhTNF in Curing Malignancy Pericardial Effusion of Advanced Tumor,Immunological Effects of Exosomes from Colorectal Cancer Cells Induced by Shocked Heat,Influence of Ad-EGFP-MDR1 on Mice Bone Marrow Cells,Construction of Anaerobic Infant Bifidobacterial Mediated pTRKH2-PsT/CD and pTRKH2-PsT/UPRT Dual Suicide System for Tumortargetting Gene Therapy,Factors Contributed to Anticancer and Adverse Effects in Advanced Adenocarcinoma of Lung with Iressa Abstract: 摘要 联合细菌的溶瘤治疗（combined bacteriolytic therapy，COBALT）策略在实体瘤治疗中方兴未艾。此策略是将专性厌氧菌Clostridium novyi-NT联合传统放化疗药物治疗实体瘤，现处于临床Ⅰ期试验阶段。本文分别从有效性及安全性等方面总结了抗肿瘤细菌应具有的标准，并简述了C. novyi-NT 的溶瘤机制
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