人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系
DOI: 10.3971/j.issn.1000-8578.2015.02.020
Keywords: 人类白细胞抗原-E,聚合酶链反应-序列特异性引物,乳腺癌,多态性,Multi-factors Affect Cardiac Toxicity in Radiotherapy on Left-sided Breast Cancer,Effect of Neoadjuvant Chemotherapy Cycles on Pathologic Complete Response Rate Under Different Estrogen Receptor Status of Breast Cancer,Review of Targeted Therapy for Breast Cancer with BRCA Genes Mutation,Autophagic Cell Death Induced by GANT61 Inhibits Proliferation of Human Breast Cancer Cell Line MCF-7,Effect of Thyroid Hormone Receptor βΔ on Proliferation and Apoptosis of Rat Breast Cancer Cells SHZ-88,Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility,Progress on FOXP3 Expression in Breast Cancer Cells,Effect of Hormones from Adrenal Gland on Breast Cancer Metastasis in Mice,Effect of SAHA on Proliferation and Apoptosis of Breast Cancer Cells MDA-MB-435 and Related Mechanism,Analysis E-cad and VEGF Expression in Triple-negative Breast Cancer of Han and Uygur,Regulations and Roles of Breast Cancer Stem Cells,Prediction of Disease Specific Survival Rates by Genes Associated with Relapse of Breast Cancer,Correlation Between Tumor Associated Macrophages and CXCL12 Expression in Different Breast Tissues,Effects of NRP-1 Overexpression on Biological Behaviors of Breast Cancer Cell Lines MDA-MB-231 and SK-BR-3,Effect of Operation Incision Selection on Success rate of Sentinel Lymph Node Biopsy and Subcutaneous Hydrops in Breast Cancer
Abstract:
摘要 目的 探讨人类白细胞抗原-E（HLA-E） 基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性的关系。方法 采用聚合酶链反应-序列特异性引物（PCR-SSP）法对中国张家口地区200例乳腺癌患者和114例健康对照人群HLA-E等位基因进行检测。结果 乳腺癌患者和健康对照组均检出两种等位基因：HLA-E*0101和HLA-E*0103；共检出三种基因型：HLA-E*0101/ HLA-E*0101、HLA-E*0101/HLA-E*0103和HLA-E*0103/ HLA-E*0103。其中HLA-E*0103等位基因和HLA-E*0103/HLA-E*0103基因型在乳腺癌患者组的分布频率明显高于健康对照组，差异有统计学意义（P ＜0.01）。且携带HLA-E*0103/ HLA-E*0103基因型的个体乳腺癌发病风险明显增加（OR=2.05,P=0.004）。结论 HLA-E基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性相关，并且HLA-E*0103/ HLA-E*0103等位基因可能是易感基因
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