%0 Journal Article
%T 人类白细胞抗原-E基因多态性与乳腺癌遗传易感性的关系
%A 吴振村
%A 周艳
%A 程健君
%A 贾天军
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.02.020
%X 摘要 目的 探讨人类白细胞抗原-E（HLA-E） 基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性的关系。方法 采用聚合酶链反应-序列特异性引物（PCR-SSP）法对中国张家口地区200例乳腺癌患者和114例健康对照人群HLA-E等位基因进行检测。结果 乳腺癌患者和健康对照组均检出两种等位基因：HLA-E*0101和HLA-E*0103；共检出三种基因型：HLA-E*0101/ HLA-E*0101、HLA-E*0101/HLA-E*0103和HLA-E*0103/ HLA-E*0103。其中HLA-E*0103等位基因和HLA-E*0103/HLA-E*0103基因型在乳腺癌患者组的分布频率明显高于健康对照组，差异有统计学意义（P ＜0.01）。且携带HLA-E*0103/ HLA-E*0103基因型的个体乳腺癌发病风险明显增加（OR=2.05,P=0.004）。结论 HLA-E基因多态性与中国张家口地区汉族女性乳腺癌遗传易感性相关，并且HLA-E*0103/ HLA-E*0103等位基因可能是易感基因
%K 人类白细胞抗原-E
%K 聚合酶链反应-序列特异性引物
%K 乳腺癌
%K 多态性
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%U http://www.zlfzyj.com/CN/abstract/abstract8428.shtml