胰腺癌肝转移患者多学科综合治疗临床分析
DOI: 10.3971/j.issn.1000-8578.2015.02.012
Keywords: 胰腺癌,肝转移,多学科综合治疗,Efficacy of IMRT Combined with Capecitabine Concurrent Chemotherapy and High Intensity Focused Ultrasound for Elderly Patients with Non-operatable Pancreatic Cancer,Progress of miRNAs Related to Pancreatic Cancer,One Case Report of Ablation by Nano Knife on Unresectable Liver Metastases from Colon Cancer,Effect of ABCG2 Expression on Chemoresistance of Pancreatic Carcinoma Cell Line#br# SW1990,125I Seed Implantation Combined with Chemotherapy for Colorectal Cancer with Postoperative Liver Metastasis,Review on Low-molecular-weight Heparin in Improving Prognosis of Pancreatic Cancer,Clinical Signifi cance of Decoy Receptor 3 Expression in Pancreatic Carcinoma,Role of Surgery for Limited Liver Metastases from Nasopharyngeal Carcinoma,Effects of SDF-1 and CXCR4 on HPA Expression in Liver Metastases Induced by Colorectal Cancer Cells,Correlation between miR-375 and PDK1 Expression in Pancreatic Cancer Tissues,Experimental Study on Inducing Apoptosis of Human Pancreatic Carcinoma Cells PANC-1 by Pseudomonas Aeruginosa Vaccinein in vitro,Effect of 5-Aza-CdR on Invasion and Migration of Pancreatic Carcinoma Cell Line PANC-1
Abstract:
摘要 目的 对胰腺癌肝转移患者的临床特征及不同治疗模式分析，探讨不同治疗模式对患者生存预后的影响。方法 回顾性分析2009年1月至2012年1月重庆医科大学附属第一医院64例胰腺癌肝转移患者的临床资料，对其临床特征和治疗模式分别用Kaplan-Meier法及Cox模型进行单因素及多因素分析。结果 64例患者总的中位生存时间（median survival time, MST）为4月，6月、1年及2年生存率（overall survival, OS）分别为39.1%、21.9%和7.8%。单因素分析显示，年龄、疼痛、厌食、CA19-9水平、ALT和GGT水平、手术、介入化疗栓塞/介入化疗、积极治疗及多学科综合治疗是预后影响因素。多因素分析示：肝外转移、疼痛、CA19-9、积极治疗、手术、介入化疗栓塞/介入化疗及多学科综合治疗与生存预后密切相关。结论 对胰腺癌肝转移患者，疼痛、CA19-9≥1 000 u/ml及合并肝外转移提示预后不良。积极治疗、手术、介入化疗栓塞/介入化疗及多学科综合治疗可明显提高患者生活质量，延长生存时间
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