肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展
DOI: 10.3971/j.issn.1000-8578.2015.11.024
Keywords: 肿瘤相关巨噬细胞,肿瘤微环境,肿瘤转移,肿瘤干细胞,Expression and Clinical Significance of Stem Cells Gene Lgr5 in Esophageal Squamous Cell Carcinoma Tissues,Correlation of CD68+ Tumor-associated Macrophages Number with Ki-67 Expression and Prognosis of Patients with Primary Hepatocellular Carcinoma,Correlation Between Tumor Associated Macrophages and CXCL12 Expression in Different Breast Tissues,Sulforaphane Suppressed Proliferation of Lung Cancer Stem Cells in vitro,Construction of RNAi Targeting CLU Gene and Effect of CLU on Biological Function of Nasopharyngeal Cancer Cells,Difference of Self-renewal and Tumorigenicity among Different Breast Cancer Stem Cells Subpopulations,Role of Cancer-associated Fibroblasts in Occurrence and Development of Colorectal Cancer,Progress of Correlation of Cell Membrane Phospholipids with Invasion, Metastasis and Targeted Therapeutics of Tumor,Progress in Relationship between Sox2 Gene and Cancer,Effect of Interfering Tumor Microenvironment on Homing and Killing Activity of Cytotoxic T Lymphocytes,Recent Progress on Isolating Bladder Cancer Stem Cells,Effect of Store-operated Calcium Entry on Tumor Metastasis,Role of Pro-apoptotic Protein Siva1 in Tumor,Tumor-associated Macrophages Development and Treatment of Tumor
Abstract:
摘要 众所周知，在肿瘤发生发展的各个阶段都有单核细胞通过血管壁进入肿瘤组织，这些单核细胞可分化形成具有独特表型的巨噬细胞，即肿瘤相关巨噬细胞（tumor-associated macrophages,TAMs）。TAMs是肿瘤微环境的重要组成部分，参与了肿瘤的发生、生长、侵袭及转移过程，其中，向肿瘤组织的转移是肿瘤恶性发展的关键步骤。本文将TAMs在肿瘤微环境形成中发挥作用的最新进展进行了总结，特别值得注意的是，细胞及动物实验研究表明，TAMs可为肿瘤的发生发展进程提供一个有利的微环境；同时，临床病理实验表明，TAMs在肿瘤内的累积与较差的临床疗效相关。最后，本文讨论了靶向TAMs的治疗手段作为一种间接癌症治疗新方法的可行性
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