%0 Journal Article
%T 肿瘤相关巨噬细胞在肿瘤微环境中的作用新进展
%A 张晓磷
%A 李海涛
%A 田书梅
%A 谭超
%A 赵云云
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.11.024
%X 摘要 众所周知，在肿瘤发生发展的各个阶段都有单核细胞通过血管壁进入肿瘤组织，这些单核细胞可分化形成具有独特表型的巨噬细胞，即肿瘤相关巨噬细胞（tumor-associated macrophages,TAMs）。TAMs是肿瘤微环境的重要组成部分，参与了肿瘤的发生、生长、侵袭及转移过程，其中，向肿瘤组织的转移是肿瘤恶性发展的关键步骤。本文将TAMs在肿瘤微环境形成中发挥作用的最新进展进行了总结，特别值得注意的是，细胞及动物实验研究表明，TAMs可为肿瘤的发生发展进程提供一个有利的微环境；同时，临床病理实验表明，TAMs在肿瘤内的累积与较差的临床疗效相关。最后，本文讨论了靶向TAMs的治疗手段作为一种间接癌症治疗新方法的可行性
%K 肿瘤相关巨噬细胞
%K 肿瘤微环境
%K 肿瘤转移
%K 肿瘤干细胞
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%K Effect of Interfering Tumor Microenvironment on Homing and Killing Activity of Cytotoxic T Lymphocytes
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%K Effect of Store-operated Calcium Entry on Tumor Metastasis
%K Role of Pro-apoptotic Protein Siva1 in Tumor
%K Tumor-associated Macrophages Development and Treatment of Tumor
%U http://www.zlfzyj.com/CN/abstract/abstract8647.shtml