结直肠癌组织中Krüppel样因子17的表达及其与预后的关系
DOI: 10.3971/j.issn.1000-8578.2015.03.010
Keywords: 结直肠癌,预后,Krü,ppel样因子17,肠梗阻,免疫组织化学,Trends on Morbidity of Colorectal Cancer Among Residents in Xining City of Qinghai Province, 2009-2014,Effects of RNAi Silencing GTPBP4 Gene on Proliferation and Apoptosis of Colon Cancer RKO Cells,Effect of Jinlong Capsule on Vasculogenic Mimicry and Mig-7 of Colon Cancer,Expression and Correlation of Id-1, MMP-9 and LMVD in Colorectal Adenocarcinoma Tissues,Effect of PTTG1 Expression on Invasion and Migration of Colon Cancer Cell SW480 and Its Possible Mechanism,One Case Report of Ablation by Nano Knife on Unresectable Liver Metastases from Colon Cancer,UGCG is Involved in Oxaliplatin Resistance Mechanism of Human Colon Cancer Through Regulating MDR1/P-gp Expression,Mortality Trend of Colorectal Cancer in Kunshan City, Jiangsu Province, 1981-2014,Recent Advances of Correlation of Mismatch Repair System hMutS, hMutL Variation and Colorectal Cancer,Role of miR-138 in Invasion of Human Colon Cancer Cells SW620 by Regulating PDK1 Expression,Research Progress of Association of Vitamin D3 and Colorectal Cancer,Effect of AT Motif Binding Factor 1 on Proliferation and Invasion of Colorectal Carcinoma Cell Line LOVO,Effects of Different Doses of Bevacizumab on Irinotecan Distribution in Nude Mice Bearing Human Colon Cancer Cell Xenografts,Clinical Significance of Different Human mcl1 Subtypes Expression in Colorectal Cancer Tissues,Relationship Between FoxQ1 and Epidermal Growth Factor Receptor Gene Expression in Colorectal Cancer
Abstract:
摘要 目的 研究Krüppel样因子17(Krüppel-like factor 17, KLF17)在结直肠癌组织中的表达及其与患者临床病理特征及预后的关系。方法 收集武汉市第一医院128例结直肠癌患者的临床病理资料，采用免疫组织化学法检测KLF17在结直肠癌及对应的非癌结直肠黏膜组织中的表达，Kaplan-Meier法绘制生存曲线，Cox比例风险模型进行生存分析。结果 128例结直肠癌中，83例癌组织存在KLF17低表达。KLF17低表达与结直肠癌患者淋巴结转移相关（P=0.012）。KLF17低表达患者5年无病生存率及总生存率分别为46.3%和49.3%，明显低于KLF17高表达患者的78.3%和82.0%（P均=0.001）。Cox 模型分析结果显示：KLF17、术前肠梗阻、肿瘤分化程度和病理学N分期是结直肠癌患者无病生存时间及总生存时间的独立预后因素（P均＜0.05）。结论 KLF17低表达与结直肠癌淋巴结转移相关，是结直肠癌患者预后不良的一个潜在分子指标
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