%0 Journal Article
%T 结直肠癌组织中Krüppel样因子17的表达及其与预后的关系
%A 冯燕
%A 吴彪
%A 孟庆彬
%A 易继林
%A 王静
%A 瞿紫微
%A 肖新波
%A 邵永胜
%A 闵凯
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.03.010
%X 摘要 目的 研究Krüppel样因子17(Krüppel-like factor 17, KLF17)在结直肠癌组织中的表达及其与患者临床病理特征及预后的关系。方法 收集武汉市第一医院128例结直肠癌患者的临床病理资料，采用免疫组织化学法检测KLF17在结直肠癌及对应的非癌结直肠黏膜组织中的表达，Kaplan-Meier法绘制生存曲线，Cox比例风险模型进行生存分析。结果 128例结直肠癌中，83例癌组织存在KLF17低表达。KLF17低表达与结直肠癌患者淋巴结转移相关（P=0.012）。KLF17低表达患者5年无病生存率及总生存率分别为46.3%和49.3%，明显低于KLF17高表达患者的78.3%和82.0%（P均=0.001）。Cox 模型分析结果显示：KLF17、术前肠梗阻、肿瘤分化程度和病理学N分期是结直肠癌患者无病生存时间及总生存时间的独立预后因素（P均＜0.05）。结论 KLF17低表达与结直肠癌淋巴结转移相关，是结直肠癌患者预后不良的一个潜在分子指标
%K 结直肠癌
%K 预后
%K Krü
%K ppel样因子17
%K 肠梗阻
%K 免疫组织化学
%K Trends on Morbidity of Colorectal Cancer Among Residents in Xining City of Qinghai Province
%K 2009-2014
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%K UGCG is Involved in Oxaliplatin Resistance Mechanism of Human Colon Cancer Through Regulating MDR1/P-gp Expression
%K Mortality Trend of Colorectal Cancer in Kunshan City
%K Jiangsu Province
%K 1981-2014
%K Recent Advances of Correlation of Mismatch Repair System hMutS
%K hMutL Variation and Colorectal Cancer
%K Role of miR-138 in Invasion of Human Colon Cancer Cells SW620 by Regulating PDK1 Expression
%K Research Progress of Association of Vitamin D3 and Colorectal Cancer
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%K Clinical Significance of Different Human mcl1 Subtypes Expression in Colorectal Cancer Tissues
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%U http://www.zlfzyj.com/CN/abstract/abstract8443.shtml