肾细胞癌的分子遗传学改变研究进展
DOI: 10.3971/j.issn.1000-8578.2018.17.1111
Keywords: 肾细胞癌,透明细胞性肾细胞癌,乳头状肾细胞癌,嫌色性肾细胞癌,基因突变,拷贝数变异,Effect of Long-chain Non-coding RNA FILNC1 Targeting c-Myc Expression on Biological Behavior of Renal Cell Carcinoma,Research Progress of Lung Cancer in Young Patients,Expression of PTEN and EMMPRIN in Lung Adenocarcinoma Tissues and Their Correlation with EGFR Mutation,Current Research Status of NF-kappa B Related Molecular Pathway in Diffuse Large B Cell Lymphoma,Updates of Immunotherapy on Renal Cell Carcinoma,Effects of Silencing EZH2 Gene Expression on Proliferation and Apoptosis of Human Renal Carcinoma Cell Lines,Relationship of Clinical Characteristics and EGFR, K-RAS Mutation in Lung Adenocarcinoma Patients with Predominant Ground-glass Opacity,Genetic Research Progress of Pancreatic Precancerous Lesions,Proliferative Role of Notch1 Signaling in Renal Cell Carcinoma,Expression and Significance of NDRG-1 and MMP-7 in Renal Cell Carcinoma,Treatment Effect and Prognostic Factors of Postoperative Therapy for 63 Patients with Renal Cell Carcinoma,Influence of p53 Mutation Status in Tumor Cells to Gene Therapy of Adv-p53,Expression of ezrin in Human Renal Cell Carcinoma and Its Significance,Study On DNA Polymeraseβ Gene Mutation in Human Nasopharyngeal Cancer
Abstract:
摘要 肾细胞癌（RCC）是肾癌最重要的一种病理分型，其中又以透明细胞性肾细胞癌（ccRCC）最常见，其次是乳头状肾细胞癌（PRCC）和嫌色性肾细胞癌（ChRCC）。随着二代测序技术的普遍运用，关于ccRCC中VHL、PBRM1等常见突变基因以及3p缺失等拷贝数变异（CNV）的研究越来越多；另外，PRCC和ChRCC中的基因突变和CNV研究也不断出现。本文将对ccRCC、PRCC和ChRCC等几种常见RCC的基因突变、CNV和基因融合等分子遗传学改变研究进展作一综述
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