%0 Journal Article
%T 肾细胞癌的分子遗传学改变研究进展
%A 席志军审校
%A 王杰综述
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.1111
%X 摘要 肾细胞癌（RCC）是肾癌最重要的一种病理分型，其中又以透明细胞性肾细胞癌（ccRCC）最常见，其次是乳头状肾细胞癌（PRCC）和嫌色性肾细胞癌（ChRCC）。随着二代测序技术的普遍运用，关于ccRCC中VHL、PBRM1等常见突变基因以及3p缺失等拷贝数变异（CNV）的研究越来越多；另外，PRCC和ChRCC中的基因突变和CNV研究也不断出现。本文将对ccRCC、PRCC和ChRCC等几种常见RCC的基因突变、CNV和基因融合等分子遗传学改变研究进展作一综述
%K 肾细胞癌
%K 透明细胞性肾细胞癌
%K 乳头状肾细胞癌
%K 嫌色性肾细胞癌
%K 基因突变
%K 拷贝数变异
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%U http://www.zlfzyj.com/CN/abstract/abstract9144.shtml