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- 2015
胶质瘤中MicroRNA-184的表达及其预后价值DOI: 10.3971/j.issn.1000-8578.2015.05.014 Keywords: A Clinicopathological Analysis of Seven Cases,Role of Aquaporin-4 in Migration of Human Astrocytoma,Research Status and Development of Adherens Junction Associated Protein-1 in Gliomas,Effects of Vascular Endothelial Cells on Invasion of Glioma Cells via Notch Signal Pathway,Clinical Analysis of Temozolomide Combined with Radiotherapy on High-grade Glioma,Role of IL-1RAP in Gliomas Cells and Its Relationship with STAT3,Acute Haematological Toxicity for Patients Treated with Craniospinal Irradiation Helical Tomotherapy Versus Conventional Radiotherapy,ERK2 Expression in Human Glioma Tissues and Its Clinical Significance Abstract: 摘要 目的 研究人脑胶质瘤石蜡包埋组织（formalin-fixed paraffin-embedded, FFPE）中微小RNA-184（microRNA-184, miR-184）的表达及其与临床病理特征之间的关系，探讨其在预测胶质瘤患者预后中的价值。方法 采用微阵列芯片法和RT-PCR检测108例胶质瘤FFPE和32例正常脑组织中的miR-184表达，同时Kaplan-Meier法分析胶质瘤患者总生存期和无病生存期情况。结果 胶质瘤组织中miR-184的表达下调，并用RT-PCR进一步验证； miR-184低表达与WHO分级（P=0.007）、Karnofsky 评分（KPS）（P=0.029）、复发时间（P=0.037）和生存时间（P=0.019）显著相关；Kaplan-Meier 分析结果表明，miR-184低表达与高表达患者总生存期（OS）（P=0.001）和无病生存期（DFS）（P=0.006）差异有统计学意义，miR-184低表达患者预后较差。多因素分析显示胶质瘤中miR-184的差异表达是预测OS[风险比（HR）：7.52；95％CI：2.63~21.42；P=0.002]和DFS[HR：11.56；95％CI：5.17~25.93；P<0.001]的独立危险因素。结论 miR-184的表达与胶质瘤患者预后显著相关，表明miR-184可作为预测胶质瘤患者预后的独立标志物
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