%0 Journal Article
%T 胶质瘤中MicroRNA-184的表达及其预后价值
%A 唐立华
%A 胡余昌
%A 郎博娟
%A 陈路
%A 马金阳
%J 肿瘤防治研究
%D 2015
%R 10.3971/j.issn.1000-8578.2015.05.014
%X 摘要 目的 研究人脑胶质瘤石蜡包埋组织（formalin-fixed paraffin-embedded, FFPE）中微小RNA-184（microRNA-184, miR-184）的表达及其与临床病理特征之间的关系，探讨其在预测胶质瘤患者预后中的价值。方法 采用微阵列芯片法和RT-PCR检测108例胶质瘤FFPE和32例正常脑组织中的miR-184表达，同时Kaplan-Meier法分析胶质瘤患者总生存期和无病生存期情况。结果 胶质瘤组织中miR-184的表达下调，并用RT-PCR进一步验证； miR-184低表达与WHO分级（P=0.007）、Karnofsky 评分（KPS）（P=0.029）、复发时间（P=0.037）和生存时间（P=0.019）显著相关；Kaplan-Meier 分析结果表明，miR-184低表达与高表达患者总生存期（OS）（P=0.001）和无病生存期（DFS）（P=0.006）差异有统计学意义，miR-184低表达患者预后较差。多因素分析显示胶质瘤中miR-184的差异表达是预测OS[风险比（HR）：7.52；95％CI：2.63~21.42；P=0.002]和DFS[HR：11.56；95％CI：5.17~25.93；P<0.001]的独立危险因素。结论 miR-184的表达与胶质瘤患者预后显著相关，表明miR-184可作为预测胶质瘤患者预后的独立标志物
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%U http://www.zlfzyj.com/CN/abstract/abstract8494.shtml