肺腺癌组织中MACC1和c-Met蛋白的表达及其与患者术后复发的关系
DOI: 10.3971/j.issn.1000-8578.2016.07.010
Keywords: 结肠癌转移相关基因1,c-Met,肺腺癌,复发,Effect of Cisplatin Combined with Buzhong Yiqi Decoction on survivin Expression in Transplantation Tumor of Nude Mice with A549/DDP Cells,Prediction of Disease Specific Survival Rates by Genes Associated with Relapse of Breast Cancer,Predictive Factors for Customizing Chemotherapy on Advanced Lung Adenocarcinoma,Value of 21-gene Assay in Treatment Decisions for Hormone Receptor-positive Nodepositive Early Breast Cancer,Role of IL-6 in Progress of Estrogen Promoting Lung Adenocarcinoma in Mice and Its Mechanism,Killing Effect of Paclitaxel and Cisplatin on EGFR-wild and Mutant Lung Adenocarcinoma Cells and Related Molecular Mechanism,‘Phoenix Rising’ Pathway on Tumor Recurrence and Metastasis,Effect of Hinokitiol Combined with Chloroquine on Apoptosis of Human Lung Adenocarcinoma Cells,Effects of Gefitinib Combined with Bruceolic Oil Emulsion on Human Lung Adenocarcinoma Cell Lines and Its Mechanism,Relationship between Local Recurrence and Anterior Commissure Involvement in Early Glottic Laryngocarcinoma after Radiofrequency Coblation,Optimized Chemotherapy Scheme for Advanced Lung Adenocarcinoma Patients,Role of Hepatocyte Growth Factor Receptor c-met Regulating Epithelial-mesenchymal Transition in Metastasis of Colorectal Cancer,Efficacy of Different Treatment Methods for Early Prostate Cancer Patients and Risk Factors for Biochemical Recurrence,Recent Advances of G-CSF Priming in Chemotherapy for Refractory or Recurrent Acute Leukemia,Bevacizumab in Treatment of Recurrent Ovarian Cancer
Abstract:
摘要 目的 检测MACC1、c-Met蛋白在肺腺癌组织中的表达，及其在患者术后复发中的预测价值。方法 收集完全性切除的肺腺癌患者术后病理标本102例和癌旁组织57例，采用免疫组织化学技术检测MACC1和c-Met蛋白在肺腺癌和癌旁组织中的表达，对患者行定期随访，分析MACC1和c-Met 蛋白的表达与患者术后复发的关系。结果 MACC1和c-Met在癌组织中的阳性表达率分别为59.80%、54.90%，明显高于癌旁组织中的7.01%、10.53%，差异有统计学意义（P<0.05）。MACC1、c-Met蛋白的表达与性别年龄无关，与肿瘤T分期、淋巴结转移、病理TNM分期有关（P<0.05）。MACC1与c-Met 的表达之间呈正相关（r=0.262, P=0.008）。MACC1阳性组2年内复发率为73.77%，明显高于阴性组的31.71%（χ2=17.686, P<0.001）。c-Met阳性组2年内复发率为76.79%，高于阴性组的34.78%（χ2=18.272, P<0.001）。Cox回归多因素提示MACC1和c-Met蛋白的表达、术后病理分期、肿瘤T分期及淋巴结转移情况是腺癌患者复发转移的危险因素。结论 MACC1和c-Met蛋白在肺腺癌组织中表达与肿瘤T分期、淋巴结转移、病理分期有关，影响肺腺癌患者术后无瘤生存期，是复发转移的危险因素
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