%0 Journal Article
%T 肺腺癌组织中MACC1和c-Met蛋白的表达及其与患者术后复发的关系
%A 周永乐
%A 哈敏文
%A 张璇
%A 李萍
%J 肿瘤防治研究
%D 2016
%R 10.3971/j.issn.1000-8578.2016.07.010
%X 摘要 目的 检测MACC1、c-Met蛋白在肺腺癌组织中的表达，及其在患者术后复发中的预测价值。方法 收集完全性切除的肺腺癌患者术后病理标本102例和癌旁组织57例，采用免疫组织化学技术检测MACC1和c-Met蛋白在肺腺癌和癌旁组织中的表达，对患者行定期随访，分析MACC1和c-Met 蛋白的表达与患者术后复发的关系。结果 MACC1和c-Met在癌组织中的阳性表达率分别为59.80%、54.90%，明显高于癌旁组织中的7.01%、10.53%，差异有统计学意义（P<0.05）。MACC1、c-Met蛋白的表达与性别年龄无关，与肿瘤T分期、淋巴结转移、病理TNM分期有关（P<0.05）。MACC1与c-Met 的表达之间呈正相关（r=0.262, P=0.008）。MACC1阳性组2年内复发率为73.77%，明显高于阴性组的31.71%（χ2=17.686, P<0.001）。c-Met阳性组2年内复发率为76.79%，高于阴性组的34.78%（χ2=18.272, P<0.001）。Cox回归多因素提示MACC1和c-Met蛋白的表达、术后病理分期、肿瘤T分期及淋巴结转移情况是腺癌患者复发转移的危险因素。结论 MACC1和c-Met蛋白在肺腺癌组织中表达与肿瘤T分期、淋巴结转移、病理分期有关，影响肺腺癌患者术后无瘤生存期，是复发转移的危险因素
%K 结肠癌转移相关基因1
%K c-Met
%K 肺腺癌
%K 复发
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%U http://www.zlfzyj.com/CN/abstract/abstract8795.shtml