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- 2018
抑酸药物对小分子靶向药物吸收的影响DOI: 10.3971/j.issn.1000-8578.2018.17.0700 Keywords: A Case Report and Literature Review,Comparison of Efficacy and Safety Between Liposome-paclitaxel plus Carboplatin and Paclitaxel plus Carboplatin on Epithelial Ovarian Cancer,Short-term Efficacy of “Head-central Mixed Way” in Laparoscopic Radical Operation of Right Colon Cancer,Comparison of Efficiency and Safety Between Radiofrequency Ablation and Stereotactic Body Radiotherapy on Primary Small Hepatocellular Carcinoma,Inhibition of Antimicrobial Peptide 17BIPHE2 on Lung Adenocarcinoma A549 Cells and Related Mechanism Abstract: 摘要 胃液pH（potential hydrogen）是影响小分子靶向药物（small molecular targeted drugs, SMTD）在体内溶解的一个重要因素，而抑酸药物（antiacid drugs, AD）可通过改变胃内pH来影响一部分SMTD的溶解度，药物溶解度高，则药物吸收较好，反之若溶解度低，则药物吸收较差。为探讨AD对SMTD体内吸收的作用关系，该文对相关文献进行检索并整理。通过整理可知，达沙替尼、厄洛替尼、吉非替尼、拉帕替尼和尼洛替尼受到AD的影响较为显著，提示临床应重视AD对SMTD吸收的影响，以避免降低SMTD的吸收和疗效
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