%0 Journal Article
%T 抑酸药物对小分子靶向药物吸收的影响
%A 何霞
%A 楚明明
%A 王继生
%A 贾霖
%A 赵德华
%A 陈静
%A 韩建军
%A 龙小庆
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0700
%X 摘要 胃液pH（potential hydrogen）是影响小分子靶向药物（small molecular targeted drugs, SMTD）在体内溶解的一个重要因素，而抑酸药物（antiacid drugs, AD）可通过改变胃内pH来影响一部分SMTD的溶解度，药物溶解度高，则药物吸收较好，反之若溶解度低，则药物吸收较差。为探讨AD对SMTD体内吸收的作用关系，该文对相关文献进行检索并整理。通过整理可知，达沙替尼、厄洛替尼、吉非替尼、拉帕替尼和尼洛替尼受到AD的影响较为显著，提示临床应重视AD对SMTD吸收的影响，以避免降低SMTD的吸收和疗效
%K A Case Report and Literature Review
%K Comparison of Efficacy and Safety Between Liposome-paclitaxel plus Carboplatin and Paclitaxel plus Carboplatin on Epithelial Ovarian Cancer
%K Short-term Efficacy of “Head-central Mixed Way” in Laparoscopic Radical Operation of Right Colon Cancer
%K Comparison of Efficiency and Safety Between Radiofrequency Ablation and Stereotactic Body Radiotherapy on Primary Small Hepatocellular Carcinoma
%K Inhibition of Antimicrobial Peptide 17BIPHE2 on Lung Adenocarcinoma A549 Cells and Related Mechanism
%U http://www.zlfzyj.com/CN/abstract/abstract9115.shtml