剂量体积联合等效均匀剂量优化在鼻咽癌调强放疗危及器官优化中的应用
DOI: 10.3971/j.issn.1000-8578.2018.17.0804
Keywords: 剂量体积优化,等效均匀剂量优化,调强放疗,鼻咽癌,Therapeutic Effect of Elemene Combined with Chemoradiotherapy and Its Influence on Immune Function in Nasopharyngeal Carcinoma Patients,Progress on Comprehensive Treatment of Nasopharyngeal Cancer,Expression and Biological Functions of Sestrin2 in Nasopharyngeal Carcinoma,Prognostic Effects of Different Courses of Neoadjuvant Chemotherapy on Stage N2-3 Locally Advanced Nasopharyngeal Carcinoma,RNA PolymeraseⅠInhibitor Regulates Proliferation, Invasion and Apoptosis of Nasopharyngeal Carcinoma Cell Line CNE-1 by NF-κb,Multi-center Clinical Study of Nimotuzumab Combined with PF Regimen in Induction Treatment of Locally Advanced Nasopharyngeal Carcinoma,Effect of Modified Yangyin Qingfei Decoction Combined with Nutritional Intervention on Nutritional Status and Curative Effect of Nasopharyngeal Carcinoma Patients Undergoing Radiotherapy,Metadherin-mediated Cell Proliferation and Paclitaxel Resistance in Nasopharyngeal Carcinoma,Relationship of Peripheral Blood Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio with Curative Effect and Prognosis of Patients with Locally Advanced Nasopharyngeal Carcinoma,An Interpretation of International Guideline for Delineation of Clinical Target Volumes for Nasopharyngeal Carcinoma in 2017,Clinical Efficacy of Gemcitabine plus S-1 on Refractory Nasopharyngeal Carcinoma Patients and Their Influence on Immune Function,Garcinone E Inhibits Proliferation, Migration and Invasion of Human Nasopharyngeal Carcinoma Cells,Expressions of PLAC8 Protein in Nasopharyngeal Carcinoma Cells and Related Clinical Significance,Effect of NLR and PLR from Pre-treatment on Prognosis of Nasopharyngeal Carcinoma Patients
Abstract:
摘要 目的 研究剂量体积优化（dose-volume, DV）联合等效均匀剂量（equivalent uniform dose, EUD）优化在鼻咽癌调强放疗危及器官优化中的应用。方法 选取西南医科大学附属医院肿瘤科放疗室鼻咽癌患者调强放疗计划55例，制作调强计划时优化方法分为常规DV优化法和DV与EUD联合优化法两种，比较两种优化方法优化后靶区与危及器官的受量。结果 常规DV优化和DV与EUD联合优化后肿瘤靶区处方剂量、均匀性指数与适形度指数之间差异均无统计学意义（均P>0.05），危及器官平均剂量差异均有统计学意义，DV与EUD联合优化得到的危及器官平均剂量低于常规DV优化（均P<0.001）。结论 本研究将DV优化与EUD联合优化法成功应用于鼻咽癌调强放疗危及器官的优化中，并在此基础上提出一种调强计划危及器官受量的验收方法，减少调强放疗计划中人为主观因素对危及器官受量的影响
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