%0 Journal Article
%T 剂量体积联合等效均匀剂量优化在鼻咽癌调强放疗危及器官优化中的应用
%A 孙小杨
%A 庞皓文
%A 杨波
%J 肿瘤防治研究
%D 2018
%R 10.3971/j.issn.1000-8578.2018.17.0804
%X 摘要 目的 研究剂量体积优化（dose-volume, DV）联合等效均匀剂量（equivalent uniform dose, EUD）优化在鼻咽癌调强放疗危及器官优化中的应用。方法 选取西南医科大学附属医院肿瘤科放疗室鼻咽癌患者调强放疗计划55例，制作调强计划时优化方法分为常规DV优化法和DV与EUD联合优化法两种，比较两种优化方法优化后靶区与危及器官的受量。结果 常规DV优化和DV与EUD联合优化后肿瘤靶区处方剂量、均匀性指数与适形度指数之间差异均无统计学意义（均P>0.05），危及器官平均剂量差异均有统计学意义，DV与EUD联合优化得到的危及器官平均剂量低于常规DV优化（均P<0.001）。结论 本研究将DV优化与EUD联合优化法成功应用于鼻咽癌调强放疗危及器官的优化中，并在此基础上提出一种调强计划危及器官受量的验收方法，减少调强放疗计划中人为主观因素对危及器官受量的影响
%K 剂量体积优化
%K 等效均匀剂量优化
%K 调强放疗
%K 鼻咽癌
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%U http://www.zlfzyj.com/CN/abstract/abstract9123.shtml