Insulin resistance is associated with depression risk in polycystic ovary syndrome - Fertility and Sterility

To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). Secondary analysis of data from a multicenter randomized trial. Multicenter university-based clinical practices. Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole. The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal. Demographic, endocrine, and metabolic parameters associated with depression. In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28–4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11–4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00–4.16). Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets. La resistencia a la insulina está asociada con el riesgo de depresión en pacientes con síndrome de ovario poliquístico Evaluar la hipótesis de que la resistencia a la insulina está asociada al riesgo de depresión en pacientes con Síndrome de Ovario Poliquístico (SOP). Análisis secundario de datos de un estudio multicéntrico aleatorizado. Consultas médicas de múltiples centros universitarios. Setecientas treinta y ocho mujeres con SOP clasificadas según los criterios modificados de Rotterdam buscando embarazo, incluidas en un estudio aleatorizado comparando citrato de clomiferno vs letrozole. Se autocompletó el Cuestionario de Evaluación de Salud en Atención Primaria sobre Desórdenes Mentales para identificar depresión usando un algoritmo validado a la inclusión de las pacientes. Se recogieron los datos demográficos y antropométricos y se realizaron estudios séricos. La resistencia a la insulina fue estimada utilizando