%0 Journal Article
%T Insulin resistance is associated with depression risk in polycystic ovary syndrome - Fertility and Sterility
%A Eleni A. Greenwood
%A Esther Eisenberg
%A Heather G. Huddleston
%A Lauri A. Pasch
%A Marcelle I. Cedars
%A Richard S. Legro
%J Fertility and Sterility
%D 2018
%R https://doi.org/10.1016/j.fertnstert.2018.03.009
%X To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS). Secondary analysis of data from a multicenter randomized trial. Multicenter university-based clinical practices. Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole. The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal. Demographic, endocrine, and metabolic parameters associated with depression. In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28每4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11每4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00每4.16). Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets. La resistencia a la insulina est芍 asociada con el riesgo de depresi車n en pacientes con s赤ndrome de ovario poliqu赤stico Evaluar la hip車tesis de que la resistencia a la insulina est芍 asociada al riesgo de depresi車n en pacientes con S赤ndrome de Ovario Poliqu赤stico (SOP). An芍lisis secundario de datos de un estudio multic谷ntrico aleatorizado. Consultas m谷dicas de m迆ltiples centros universitarios. Setecientas treinta y ocho mujeres con SOP clasificadas seg迆n los criterios modificados de Rotterdam buscando embarazo, incluidas en un estudio aleatorizado comparando citrato de clomiferno vs letrozole. Se autocomplet車 el Cuestionario de Evaluaci車n de Salud en Atenci車n Primaria sobre Des車rdenes Mentales para identificar depresi車n usando un algoritmo validado a la inclusi車n de las pacientes. Se recogieron los datos demogr芍ficos y antropom谷tricos y se realizaron estudios s谷ricos. La resistencia a la insulina fue estimada utilizando
%U https://www.fertstert.org/article/S0015-0282(18)30262-0/fulltext