Leprosy is an immunopathology caused by M. leprae; its
evolution depends on immunological and genetic aspects of the host. The
objective was verifying the relationship between SNPs 2029 and 2258 of the
TLR-2 gene and leprosy. Blood samples from 127 individuals were analyzed: 45
patients, being 34 multibacillary (MB) and 11 paucibacillary (PB) and 82
contacts, in the municipalities of the State of Pará-Brazil. SNPs 2029 and 2258
of the TLR-2 gene were genotyped by sequencing on the ABI 3130 Genetic Analyzer
(Applied Biosystems), analyzed using Fisher’s exact test. Distribution of SNP
2029 genotypes: all MB individuals presented the C/C genotype and the mutant
(C/T) genotype was observed in contacts and PB. Alleles: all MB individuals
presented only C allele and the mutant allele (T) was observed in contacts and
PB. SNP 2258 genotypes: 79 contacts had G/G genotype and only 3 had G/A
genotype, the MB group had only G/G genotype and the PB group was predominant
G/G, with only 1 G/A genotype. Alleles: all MB individuals had allele G and the
mutant allele (A) was observed in contacts and PB. The association between the
SNPs and the susceptibility or protection to leprosy was not observed.
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