%0 Journal Article
%T Polymorphisms of the Toll-Like Receptor-2 Gene in Patients with Leprosy and Their Healthy Contacts
%A Luana Nepomuceno Gondim Costa Lima
%A Let¨ªcia Siqueira Moura
%A Jasna Leticia Pinto Paz
%A Maria do Perp¨¦tuo Socorro Amador Silvestre
%A Daniele Melo Sardinha
%A Let¨ªcia Diogo de Oliveira Moura
%A Karla Val¨¦ria Batista Lima
%J Open Journal of Immunology
%P 37-46
%@ 2162-4526
%D 2020
%I Scientific Research Publishing
%R 10.4236/oji.2020.103004
%X Leprosy is an immunopathology caused by <i>M. leprae</i>; its
evolution depends on immunological and genetic aspects of the host. The
objective was verifying the relationship between SNPs 2029 and 2258 of the
TLR-2 gene and leprosy. Blood samples from 127 individuals were analyzed: 45
patients, being 34 multibacillary (MB) and 11 paucibacillary (PB) and 82
contacts, in the municipalities of the State of Par¨¢-Brazil. SNPs 2029 and 2258
of the TLR-2 gene were genotyped by sequencing on the ABI 3130 Genetic Analyzer
(Applied Biosystems), analyzed using Fisher¡¯s exact test. Distribution of SNP
2029 genotypes: all MB individuals presented the C/C genotype and the mutant
(C/T) genotype was observed in contacts and PB. Alleles: all MB individuals
presented only C allele and the mutant allele (T) was observed in contacts and
PB. SNP 2258 genotypes: 79 contacts had G/G genotype and only 3 had G/A
genotype, the MB group had only G/G genotype and the PB group was predominant
G/G, with only 1 G/A genotype. Alleles: all MB individuals had allele G and the
mutant allele (A) was observed in contacts and PB. The association between the
SNPs and the susceptibility or protection to leprosy was not observed.
%K Polymorphism
%K Toll-Like Receptors
%K Leprosy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=102239