Background: Green coffee as a functional food has an antioxidant effect, which can reduce the cancer incidence, promote weight-loss and improve glucose and lipid metabolism, as well as anti-oxidant and anti-inflammatory activity. Objective: Assessing the effect of green coffee administration on experimental cisplatin induced renal apoptosis in adult male albino rats of local strain. Design: Randomized Block Design was used. Materials and Methods: Forty adult male albino rats of local strain were randomly divided into four groups of 10 animals each. G1: control negative group was received isotonic saline (0.5 ml, i.p.) for 30 consecutive days, G2: sham operated group mice were received green coffee extract in water (40 mg/kg/day) for 30 consecutive days, animals of G3 and G4 were administered cisplatin (8 mg/kg/day, i.p.) at 10th day, which is well known to produce significant nephrotoxicity in rats. Animals in G3 were received green coffee extract in water (40 mg/kg/day) and G4 was received isotonic normal saline (0.5 ml, i.p.) for 30 consecutive days. All rats were sacrificed after 30 days and blood was withdrawn for biochemical examinations of kidney function tests (blood urea nitrogen, creatinine and uric acid). Kidneys were removed for determination of renal oxidative stress markers (H2O2) biochemically and caspase-3 by Immunohistochemical examination. Results: Cisplatin administration was associated with significant higher levels of BUN, creatinine, uric acid and H2O2 as compared with normal control group. Green coffee administration in cisplatin-induced renal apoptosis groups produced significant lower levels of BUN, creatinine, uric acid and H2O2 (24.4 ± 4.14, 1.730 ± 0.2830, 5.50 ± 0.850 and 0.51 ± 0.12 respectively) as compared with cisplatin-induced renal apoptosis group not administrated green coffee (27.4 ± 6, 2.04 ± .31, 7.00 ± 1.25 and 1.1 ± 0.16 respectively). Cisplatin administration increased expression of the apoptotic protein caspase-3. In contrast, treatment with green coffee extract attenuated apoptosis. Conclusion: green coffee reduced cisplatin-induced renal apoptosis. Green coffee improved the general condition of cisplatin-induced renal apoptosis rats due to its antioxidant and anti-apoptotic effects.
References
[1]
International Coffee Organization (2013) Annual Review 2011/2012. London.
[2]
Karunanidhi, A., Thomas, R., Van Belkum, A. and Neela, V. (2013) In Vitro Antibacterial and Antibiofilm Activities of Chlorogenic Acid against Clinical Isolates of Stenotrophomonas maltophilia Including the Trimethoprim/Sulfamethoxazole Resistant Strain. BioMed Research International, 2013, Article ID: 392058.
https://doi.org/10.1155/2013/392058
[3]
Farah, A., Monteiro, M., Donangelo, C.M. and Lafay, S. (2008) Chlorogenic Acids from Green Coffee Extract Are Highly Bioavailable in Humans. The Journal of Nutrition, 138, 2309-2315. https://doi.org/10.3945/jn.108.095554
[4]
Fardiaz, S. (1995) Antimicrobial Activity of Coffee (Coffea robusta) Extract. ASEAN Food Journal, 10, 103-106.
[5]
Hartmann, J.T. and Lipp, H.P. (2003) Toxicity of Platinum Compounds. Expert Opinion on Pharmacotherapy, 4, 889-901. https://doi.org/10.1517/14656566.4.6.889
[6]
Sastry, J. and Kellie, S.J. (2005) Severe Neurotoxicity, Ototoxicity and Nephrotoxicity Following High-Dose Cisplatin and Amifostine. Pediatric Hematology and Oncology, 22, 441-445. https://doi.org/10.1080/08880010590964381
[7]
Miller, R.P., Tadagavad, R.K., Rames, H.G. and Reeves, W.B. (2010) Mechanisms of Cisplatin Nephrotoxicity. Toxins, 2, 2490-2518.
https://doi.org/10.3390/toxins2112490
[8]
Gorbounova, V. and Hirsh, V. (2010) Overall Survival with Cisplatin-Gemcitabine and Bevacizumab or Placebo as First-Line Therapy for Nonsquamous Non-Small-Cell Lung Cancer: Results from a Randomised Phase III Trial (AVAiL). Annals of Oncology, 21, 1804-1809. https://doi.org/10.1093/annonc/mdq020
[9]
Yao, X., Panichpisal, K., Kurtzman, N. and Nugent, K. (2007) Cisplatin Nephrotoxicity: A Review. The American Journal of the Medical Sciences, 334, 115-124.
https://doi.org/10.1097/MAJ.0b013e31812dfe1e
[10]
Chopra, S., Kaufman, S.S., Jones, T.W., Hong, M.K., Gerh, R.J., Hamburger, R.J. and Trump, B.F. (1982) Cis-Diaminedichloroplatinum-Induced Acute Renal Failure in the Rat. Kidney International, 21, 54-64. https://doi.org/10.1038/ki.1982.8
[11]
Schumer, M.M., O’Toole, C.A., Olsson, C.A., Wise, G.J. and Buttyan, R. (1992) Morphologic, Biochemical and Molecular Evidence of Apoptosis during the Reperfusion Phase after Brief Periods of Renal Ischemia. The American Journal of Pathology, 140, 831-838.
[12]
Cummings, B.S., McHowat, J. and Schnellmann, R.G. (2000) Phospholipases A2s in Cell Injury and Death. Journal of Pharmacology and Experimental Therapeutics, 294, 793-799.
[13]
Wyllie, A.H. (1997) Apoptosis: An Overview. British Medical Bulletin, 53, 451-465.
https://doi.org/10.1093/oxfordjournals.bmb.a011623
[14]
Wang, S., Konorev, E.A., Kotamraju, S., Joseph, J., Kalivendi, S. and Kalyanaraman, B. (2004) Doxorubicin Induces Apoptosis in Normal and Tumor Cells via Distinctly Different Mechanisms. Intermediacy of H2O2- and p53-Dependent Pathways. The Journal of Biological Chemistry, 279, 25535-25543.
https://doi.org/10.1074/jbc.M400944200
[15]
Cano-Marquina, A., Tarín, J.J. and Cano, A. (2013) The Impact of Coffee on Health. Maturitas, 75, 7-21. https://doi.org/10.1016/j.maturitas.2013.02.002
[16]
Ma, P., Zhang, S., Su, X., Qiu, G. and Wu, Z. (2015) Protective Effects of Icariin on Cisplatin-Induced Acute Renal Injury in Mice. American Journal of Translational Research, 7, 2105-2114.
[17]
Unis, A. El Basateeny, S.S. and Nassef, N.A.H. (2014) Effect of Green Coffee Bean Extract on Gentamicin Induced Acute Renal Failure in Rats. World Academy of Science, Engineering and Technology International Journal of Pharmacological and Pharmaceutical Sciences, 8, No. 5.
[18]
Malik, S., Suchal, K., Gamad, N., et al. (2015) Telmisartan Ameliorates Cisplatiniduced Nephrotoxicity by Inhibiting MAPK Mediated Inflammation and Apoptosis. European Journal of Pharmacology, 748, 54-60.
https://doi.org/10.1016/j.ejphar.2014.12.008
[19]
Hsu, S.M., Raine, L. and Fanger, H. (1981) The Use of Antiavidin Antibody and Avidin-Biotin-Peroxidase Complex in Immunoperoxidase Techniques. American Journal of Clinical Pathology, 75, 816-821. https://doi.org/10.1093/ajcp/75.6.816
[20]
Siddik, Z.H. (2003) Cisplatin: Mode of Cytotoxic Action and Molecular Basis of Resistance. Oncogene, 22, 7265-7279. https://doi.org/10.1038/sj.onc.1206933
[21]
Jiang, M. and Dong, Z. (2008) Regulation and Pathological Role of p53 in Cisplatin Nephrotoxicity. The Journal of Pharmacology and Experimental Therapeutics, 327, 300-307. https://doi.org/10.1124/jpet.108.139162
[22]
Fatima, S., Arivarasu, N.A. and Mahmood, R. (2007) Vitamin C Attenuates Cisplatin-Induced Alterations in Renal Brush Border Membrane Enzymes and Phosphate Transport. Human and Experimental Toxicology, 26, 419-426.
https://doi.org/10.1177/0960327106072389
[23]
Jilanchi, S., Nematbakhsh, M., Mazaheri, S., Talebi, A., Zolfaghari, B., Pezeshki, Z., et al. (2014) Pomegranate Flower Extract Does Not Prevent Cisplatin-Induced Nephrotoxicity in Female Rats. International Journal of Preventive Medicine, 5, 1621-1625.
[24]
Wang, H., Jia, Z., Sun, J., Xu, L., Zhao, B., Yu, K., et al. (2015) Nitrooleic Acid Protects against Cisplatin Nephropathy: Role of COX-2/mPGES-1/PGE2 Cascade. Mediators of Inflammation, 2015, Article ID: 293474.
https://doi.org/10.1155/2015/293474
[25]
Lv, X., Chen, Z., Li, J., Zhang, L., Liu, H., Huang, C. and Zhu, P. (2010) Caffeine Protects against Alcoholic Liver Injury by Attenuating Inflammatory Response and Oxidative Stress. Inflammation Research, 59, 635-645.
https://doi.org/10.1007/s00011-010-0176-6
[26]
Tiwari, K.K., Chu, C., Couroucli, X., Moorthy, B. and Lingappan, K. (2014) Differential Concentration-Specific Effects of Caffeine on Cell Viability, Oxidative Stress, and Cell Cycle in Pulmonary Oxygen Toxicity in Vitro. Biochemical and Biophysical Research Communications, 450, 1345-1350.
https://doi.org/10.1016/j.bbrc.2014.06.132
[27]
Srividya, M., Swamini, T., Krishnan, V. and Lakshman, R. (2016) Green Coffee Extract Induces Activation Markers in J774.1 Macrophages and Protects Them from Doxorubicin Induced Apoptosis. International Journal of Pharma and Bio Sciences, 7, 153-160.
Butt, M.S. and Sultan, M.T. (2011) Coffee and Its Consumption: Benefits and Risks. Critical Reviews in Food Science and Nutrition, 51, 363-373.
https://doi.org/10.1080/10408390903586412
[30]
Shahidi, F. and Chandrasekara, A. (2010) Hydroxycinnamates and Their in Vitro and in Vivo Antioxidant Activities. Phytochemistry Reviews, 9, 147-170.
https://doi.org/10.1007/s11101-009-9142-8
[31]
Dziki, D., Gawlik-Dziki, U., Pecio, L., Rozylo, R., Swieca, M., Krzykowski, A. and Rudy, S. (2015) Ground Green Coffee Beans as a Functional Food Supplement—Preliminary Study. LWT—Food Science and Technology, 63, 691-699.
https://doi.org/10.1016/j.lwt.2015.03.076
[32]
Zhang, Y., Lee, E.T., Cowan, L.D., Fabsitz, R.R. and Howard, B.V. (2011) Coffee Consumption and the Incidence of Type 2 Diabetes in Men and Women with Normal Glucose Tolerance: The Strong Heart Study. Nutrition, Metabolism and Cardiovascular Diseases, 21, 418-423. https://doi.org/10.1016/j.numecd.2009.10.020
[33]
Kim, B.H., Park, Y.S., Noh, H.M., Sung, J.S. and Lee, J.K. (2013) Association between Coffee Consumption and Renal Impairment in Korean Women with and without Diabetes: Analysis of the Fourth Korea National Health and Nutrition Examination Survey in 2008. Korean Journal of Family Medicine, 34, 265-271.
https://doi.org/10.4082/kjfm.2013.34.4.265
[34]
Kenza, B., Djihane, A., Mouad, B., Ratiba, M., Samir, B., Fadila, B. and Souad, A. (2017) Renoprotective Effect of Centaurea Choulettiana Pomel (Asteraceae) Leaves on Cisplatin—Induced Oxidative Stress and Renal Dysfunction in Mice. Journal of Applied Pharmaceutical Science, 7, 147-154.
[35]
Duncan, O.D. and Duncan, B. (1955) A Methodological Analysis of Segregation Indexes. American Sociological Association, 20, 210-217.
https://doi.org/10.2307/2088328
[36]
Cao, J., Han, J., Xiao, H., Qiao, J. and Han, M. (2016) Effect of Tea Polyphenol Compounds on Anticancer Drugs in Terms of Anti-Tumor Activity, Toxicology, and Pharmacokinetics. Nutrients, 8, 762. https://doi.org/10.3390/nu8120762
