Background: The amounts of micronutrients in the diets of infants, and the factors that influence them needs to be monitored at the population level in order to avert detrimental developmental defects that impose lifetime-limitations on an infant’s regulatory and defense systems. This study therefore, sought to evaluate if increasing levels of the toxic metals, Hg, Pb and Cd in breast milk will result in reducing amounts of the micronutrients Zn, Se and Cu in breast milk. Methods: Breast milk samples of 114 women living in two mining areas (57 women each) in Ghana, whose babies’ amounts of breast milk intake at three months postpartum, and amounts of toxic metals had previously been determined in a prospective study, were analyzed for micronutrients by a combination of acid and microwave digestion, and quantifications were by two different modes (hydrogen and helium) of Octapole Reaction System Inductively Coupled Plasma Mass Spectrometer (7500 ce. Agilent), equipped with an ASX-510 Auto-sampler (Cetac). Results: All the breast milk specimen collected contained detectable amounts of Cu, Zn, both at levels less than have been previously reported, and Se. For specimen that did not contain Pb the amount of Se ranged from about 110 to 245 ng/g of milk, however, as the amount of Pb increased, the corresponding highest detected amount of Se reduced steeply, resulting in a right-angle triangle-shaped scatter plot. Similar relationships were observed between other toxic metals and micronutrients studied. A curve fitting regression analysis showed significant quadratic and cubic relationships between the amounts of Hg and Se, as well as between Pb, As and Cu. Conclusion: The results clearly suggest a double burden of malnutrition in these mining areas, where high loads of maternal toxic metals in breast milk, related significantly with a progressive reduction in the amounts of the micronutrients Cu and Se in breast milk, potentially reducing in infants’ intake of these micronutrients.
References
[1]
Lessen, R. and Kavanagh, K. (2015) Position of the Academy of Nutrition and Dietetics: Promoting and Supporting Breastfeeding. Journal of the Academy of Nutrition and Dietetics, 115, 444–449. https://doi.org/10.1016/j.jand.2014.12.014
[2]
Kramer, M.S. and Kakuma, R. (2012) Optimal Duration of Exclusive Breastfeeding. Cochrane Database Syst. Rev. Cochrane Pregnancy and Childbirth Group.
[3]
Zwolak, I. and Zaporowska, H. (2012) Selenium Interactions and Toxicity: A Review: Selenium Interactions and Toxicity. Cell Biology and Toxicology, 28, 31-46.
https://doi.org/10.1007/s10565-011-9203-9
[4]
Sandstrom, B. (2001) Micronutrient Interactions: Effects on Absorption and Bioavailability. British Journal of Nutrition, 85, S181-S185.
https://doi.org/10.1079/BJN2000312
[5]
Peraza, M.A., Ayala-Fierro, F., Barber, D.S., Casarez, E. and Rael, L.T. (1998) Effects of Micronutrients on Metal Toxicity. Environmental Health Perspectives, 106, 203-216.
[6]
Martin, C., Ling, P.-R. and Blackburn, G. (2016) Review of Infant Feeding: Key Features of Breast Milk and Infant Formula. Nutrients, 8, 279.
https://doi.org/10.3390/nu8050279
[7]
Mahdavi, R., Nikniaz, L. and Gayemmagami, S.J. (2010) Association between Zinc, Copper, and Iron Concentrations in Breast Milk and Growth of Healthy Infants in Tabriz, Iran. Biological Trace Element Research, 135, 174-181.
https://doi.org/10.1007/s12011-009-8510-y
[8]
Dorea, J.G. (2002) Selenium and Breast-Feeding. British Journal of Nutrition, 88, 443. https://doi.org/10.1079/BJN2002692
[9]
Parr, R.M., De Maeyer, E.M., Iyengar, V.G., Byrne, A.R., Kirkbright, G.F., Schoch, G., Niinisto, L., Pineda, O., Vis, H.L., Hofvander, Y., et al. (1991) Minor and Trace Elements in Human Milk from Guatemala, Hungary, Nigeria, Philippines, Sweden, and Zaire: Results from a WHO/IAEA Joint Project. Biological Trace Element Research, 29, 51-75. https://doi.org/10.1007/BF03032674
[10]
Krebs, N.F. and Hambidge, K.M. (1986) Zinc Requirements and Zinc Intakes of Breast-Fed Infants. The American Journal of Clinical Nutrition, 43, 288-292.
https://doi.org/10.1093/ajcn/43.2.288
[11]
Bjorklund, K.L., Vahter, M., Palm, B., Grandér, M., Lignell, S. and Berglund, M. (2012) Metals and Trace Element Concentrations in Breast Milk of First Time Healthy Mothers: A Biological Monitoring Study. Environmental Health, 11.
https://doi.org/10.1186/1476-069X-11-92
[12]
Lonnerdal, B. (2009) Regulation of Mineral and Trace Elements in Human Milk: Exogenous and Endogenous Factors. Nutrition Reviews, 58, 223-229.
https://doi.org/10.1111/j.1753-4887.2000.tb01869.x
[13]
Matovic, V., Buha, A., Bulat, Z. and Dukic-Cosic, D. (2011) Cadmium Toxicity Revisited: Focus on Oxidative Stress Induction and Interactions with Zinc and Magnesium. Archives of Industrial Hygiene and Toxicology, 62.
[14]
Bansa, D.K., Awua, A.K., Boatin, R., Adom, T., Brown-Appiah, E.C., Amewosina, K.K., Diaba, A., Datoghe, D. and Okwabi, W. (2017) Cross-Sectional Assessment of Infants’ Exposure to Toxic Metals through Breast Milk in a Prospective Cohort Study of Mining Communities in Ghana. BMC Public Health, 17, 505.
https://doi.org/10.1186/s12889-017-4403-8
[15]
Combs, G.F. (2001) Selenium in Global Food Systems. British Journal of Nutrition, 85, 517. https://doi.org/10.1079/BJN2000280
[16]
Yalcin, S.S., Yalcin, S. and Gucus, A.I. (2015) Zinc and Copper Concentrations in Breast Milk during the First Nine Months of Lactation: A Longitudinal Study. Pediatrics, 135, S13-S14. https://doi.org/10.1542/peds.2014-3330X
[17]
Khaghani, S., Ezzatpanah, H., Mazhari, N., Givianrad, M.H., Mirmiranpour, H. and Sadrabadi, F.S. (2010) Zinc and Copper Concentrations in Human Milk and Infant Formulas. Iranian Journal of Pediatrics, 20, 53-57.
[18]
Peters, K.M., Galinn, S.E. and Tsuji, P.A. (2016) Selenium: Dietary Sources, Human Nutritional Requirements and Intake across Populations. In: Hatfield, D.L., Schweizer, U., Tsuji, P.A. and Gladyshev, V.N., Eds., Selenium, Springer International Publishing, Cham, 295-305. https://doi.org/10.1007/978-3-319-41283-2_25
[19]
Jolly, Y.N., Islam, A. and Akbar, S. (2013) Transfer of Metals from Soil to Vegetables and Possible Health Risk Assessment. SpringerPlus, Berlin, 2.
[20]
Zachara, B.A. and Pilecki, A. (2000) Selenium Concentration in the Milk of Breast-Feeding Mothers and Its Geographic Distribution. Environmental Health Perspectives, 108, 1043-1046. https://doi.org/10.1289/ehp.001081043
[21]
Li, P., Li, Y. and Feng, X. (2016) Mercury and Selenium Interactions in Human Blood in the Wanshan Mercury Mining Area, China. Science of the Total Environment, 573, 376-381. https://doi.org/10.1016/j.scitotenv.2016.08.098
[22]
Bjorklund, G., Aaseth, J., Ajsuvakova, O.P., Nikonorov, A.A., Skalny, A.V., Skalnaya, M.G. and Tinkov, A.A. (2017) Molecular Interaction between Mercury and Selenium in Neurotoxicity. Coordination Chemistry Reviews, 332, 30-37.
https://doi.org/10.1016/j.ccr.2016.10.009
Peterson, S.A., Ralston, N.V.C., Whanger, P.D., Oldfield, J.E. and Mosher, W.D. (2009) Selenium and Mercury Interactions with Emphasis on Fish Tissue. Environmental Bioindicators, 4, 318-334. https://doi.org/10.1080/15555270903358428
[25]
García-Sevillano, M.A., Rodríguez-Moro, G., García-Barrera, T., Navarro, F. and Gómez-Ariza, J.L. (2015) Biological Interactions between Mercury and Selenium in Distribution and Detoxification Processes in Mice under Controlled Exposure. Effects on Selenoprotein. Chemico-Biological Interactions, 229, 82-90.
https://doi.org/10.1016/j.cbi.2015.02.001
[26]
Liu, C., Zhang, L., Wu, Q., Qu, G., Yin, Y., Hu, L., Shi, J. and Jiang, G. (2018) Mutual Detoxification of Mercury and Selenium in Unicellular Tetrahymena. Journal of Environmental Sciences, 68, 143-150. https://doi.org/10.1016/j.jes.2018.02.004
[27]
Domellof, M., Lonnerdal, B., Dewey, K.G., Cohen, R.J. and Hernell, O. (2004) Iron, Zinc, and Copper Concentrations in Breast Milk are Independent of Maternal Mineral Status. The American Journal of Clinical Nutrition, 79, 111-115.
https://doi.org/10.1093/ajcn/79.1.111
[28]
Groten, J.P., Sinkeldam, E.J., Muys, T., Luten, J.B. and van Bladeren, P.J. (1991) Interaction of Dietary Ca, P, Mg, Mn, Cu, Fe, Zn and Se with the Accumulation and Oral Toxicity of Cadmium in Rats. Food and Chemical Toxicology, 29, 249-258.
https://doi.org/10.1016/0278-6915(91)90022-Y
