卵巢早衰与非早衰者受卵IVF-ET治疗结局分析
Effect of reducing number of donated eggs on IVF-ET outcomes of eggs recipients

目的:探讨卵巢早衰(POF)、非POF患者受卵IVF-ET的治疗结局及影响因素。方法:回顾性分析2012年11月至2015年1月于郑州大学第一附属医院生殖医学中心行受卵冻融胚胎移植助孕的267例POF、非POF患者和267例同期行赠卵IVF/ICSI患者的治疗情况及妊娠结局。结果:POF、非POF受卵者每个IVF周期的受卵数分别为3.98、4.13个。赠卵者新鲜移植胚胎周期和解冻移植胚胎周期的临床妊娠率分别为52.50%、63.53%,受卵POF组、非POF组解冻移植胚胎周期的临床妊娠率分别为62.96%、51.59%,4组间差异无统计学意义(P=0.099)。受卵非POF解冻移植胚胎周期的单胎活产率低于赠卵新鲜移植胚胎周期和解冻移植胚胎周期(P<0.05)。赠、受双方IVF/ICSI周期的受精率、胚胎形成率、优质胚胎形成率及胚胎移植周期的胚胎种植率比较,差异均无统计学意义(P＞0.05)。结论:赠卵IVF-ET治疗中适当减少赠卵数并不影响赠、受卵者的治疗结局。
Aim: To investigate the influence of reducing the number of donated eggs on the IVF-ET outcomes of eggs recipients with and without premature ovarian failure(POF).Methods: Retrospective clinical study of 267 patients received eggs that was performed in POF and non-POF and 267 patients donated eggs from Nov.2012 to Jan.2015.Results: In each IVF cycle,the number of eggs received by patients with POF and without POF were 3.98 and 4.13,respectively.The clinical pregnancy rate of donors' IVF-ET cycles and thaw-ET cycles were 52.50% and 63.53%,respectively,the clinical the clinical pregnancy rate of recipients with POF and without POF were 62.96% and 51.59%, respectively,and there was no significant difference(P=0.099). Among the clinical outcomes, the non-POF recipients' singletons live-birth rate was lower than that of the donors in both IVF-ET cycles and thaw-ET cycles(P<0.05).The fertilization rate,cleavage rate,embryo formation rate,high quality embryo formation rate and the embryo implantation rate per cycle had no significant difference between the eggs donors and recipients(P＞0.05).Conclusion: In the donor egg IVF-ET,reducing the number of donated eggs appropriately will not influence the pregnancy outcomes of eggs donors and recipients