微小RNA-203的生物学功能及其在口腔疾病中的作用
Biological functions of microRNA-203 and its role in oral diseases

摘要： 微小RNA-203（miR-203）具有多种生物学功能，可在不同水平调控下游基因的表达，参与肿瘤和炎症的形成和进展，是肿瘤早期诊断和预后判断的可靠分子标志物及治疗靶点。随着对炎症微环境下肿瘤形成机制的深入研究，miR-203调节炎症相关肿瘤的机制成为新的研究热点。近年来，miR-203在口腔疾病中的作用引起了学者的关注，本文就miR-203的生物学功能，miR-203与口腔疾病的关系等研究进展作一综述。
Abstract: MicroRNA-203(miR-203) plays important roles in the development and progression of tumor and inflammation by targeting and regulating various downstream mediators at different levels. MiR-203 is a novel diagnostic and prognostic marker because of its therapeutic potential. The intensive investigation of mechanism in tumor development within micro-environment of inflammation has made the potent role of miR-203 in regulating inflammation-related tumor a new controversial issue. Recently, the regulatory mechanisms of miR-203 have been investigated in oral diseases. This mini-review focuses on the biological function of miR-203, especially its role in oral diseases