%0 Journal Article
%T 微小RNA-203的生物学功能及其在口腔疾病中的作用<br>Biological functions of microRNA-203 and its role in oral diseases
%A 耿奉雪
%A 潘亚萍
%J 国际口腔医学杂志
%D 2016
%R 10.7518/gjkq.2016.06.015
%X 摘要： 微小RNA-203（miR-203）具有多种生物学功能，可在不同水平调控下游基因的表达，参与肿瘤和炎症的形成和进展，是肿瘤早期诊断和预后判断的可靠分子标志物及治疗靶点。随着对炎症微环境下肿瘤形成机制的深入研究，miR-203调节炎症相关肿瘤的机制成为新的研究热点。近年来，miR-203在口腔疾病中的作用引起了学者的关注，本文就miR-203的生物学功能，miR-203与口腔疾病的关系等研究进展作一综述。<br>Abstract: MicroRNA-203(miR-203) plays important roles in the development and progression of tumor and inflammation by targeting and regulating various downstream mediators at different levels. MiR-203 is a novel diagnostic and prognostic marker because of its therapeutic potential. The intensive investigation of mechanism in tumor development within micro-environment of inflammation has made the potent role of miR-203 in regulating inflammation-related tumor a new controversial issue. Recently, the regulatory mechanisms of miR-203 have been investigated in oral diseases. This mini-review focuses on the biological function of miR-203, especially its role in oral diseases
%K 微小RNA-203
%K 肿瘤
%K 炎症
%K 抑癌基因
%K 炎症微环境
%K &lt
%K /br&gt
%K microRNA-203
%K tumor
%K inflammation
%K tumor suppressor gene
%K inflammation micro-environment
%U http://www.gjkqyxzz.cn/CN/10.7518/gjkq.2016.06.015