AD相关睡眠障碍可能与BF区胆碱能对腺苷的负性调控有关
AD-related sleep disorder may be related to cholinergicnegative regulation of adenosine in BF area

研究显示睡眠障碍在阿尔茨海默症（AD）患者中普遍存在，但其内在的分子机制仍不十分清楚；同时大量研究发现胆碱能与腺苷在睡眠中均起到重要作用。本文对相关文献进行研究、探讨，认为AD患者相关睡眠障碍可能与基底前脑（BF）区胆碱能对腺苷的负性调控有关。并进一步提出胆碱能-NTPDase3-腺苷-睡眠和胆碱能-NF-κB-腺苷A1R-睡眠两条调控通路。希望通过本文介绍能为AD相关睡眠障碍的分子机制研究提供参考。
Sleep disorder is common in the patients with Alzheimer’s disease (AD). However, its molecularmechanism is still a mystery. Meanwhile, lots of studies have found that both cholinergic and adenosine play importantroles in sleep. After reviewing a large number of related literatures and making a lot of discussion, we thought that ADrelatedsleep disorder might be related to cholinergic negative regulation of adenosine in basal forebrain (BF) area.In addition, we put forward two regulatory pathways: cholinergic–NTPDase3–adenosine–sleep and cholinergic–NF-κB–adenosine–A1R–sleep. We hope that these would be able to provide useful reference for the studies on the molecularmechanism of AD-related sleep disorder