转录因子AP-2家族在胚胎发育及心脏血管发育过程中均发挥着重要作用，常导致胚胎发育受阻。心脏血管发育主要与AP-2α及AP-2β两者相关，其中AP-2α主要作用于心室流出道及大动脉，而AP-2β被证实与心脏动脉导管的开放与闭合机制有关。该文系统综述了AP-2基因家族的结构、表达、在胚胎发育及心脏血管发育中的功能与途径，尤其是在动脉导管未闭发生中的最新研究进展。 ： Transcription factor AP-2 plays an important role in embryonic and cardiovascular development and often influences the development of embryo. AP-2α and AP-2β are associated with the development of cardiovascular system. AP-2α mainly affects ventricular outflow tract and arteries, while AP-2β has been identified to be involved in the opening and closing of ductus arterious. This paper systematically reviews latest research advances in the structure and expression of AP-2 gene family, as well as its functions and mechanisms in embryonic and cardiovascular development, especially in patent ductus arterious
