抵抗素基因多态性与脑梗死的关系
Correlation between polymorphism of resistin gene and cerebral infraction

目的 研究抵抗素基因-420C/G位点多态性与脑梗死之间是否存在相关性。方法 采用聚合酶链反应－高温连接酶检测反应技术，对426例脑梗死患者和305例健康对照者抵抗素基因-420C/G的多态性进行分析。结果 脑梗死组的总胆固醇（TC）与对照组比较，差异无统计学意义。脑梗死组的三酰甘油（TG）、低密度脂蛋白胆固醇(LDL-C)、血糖和血压高于对照组，而高密度脂蛋白胆固醇(HDL-C)则降低。脑梗死组患者的-420C/G基因型频率和等位基因频率与对照组比较，差异无统计学意义，两组样本都符合H-W检验。脑梗死危险因素的logistic回归分析显示，收缩压、空腹血糖、LDL-C和TG水平的差异是脑梗死的独立危险因素。结论 抵抗素基因-420C/G位点多态性与脑梗死无相关性。
： Objective To investigate the correlation between the polymorphism of locus -420C/G of the resistin gene and cerebral infraction. Methods The polymorphism of locus -420C/G of the resistin gene of 426 patients with cerebral infraction and 305 healthy controls was analyzed by PCR-LDR. Results The difference of TC between the cerebral infraction group and control group were not statistically significant. The TG, LDL-C, fasting blood glucose, and blood pressure of the cerebral infraction group were higher than those of the control group, while HDL-C was lower than that of the control group. The differences of genotype frequency and allele frequency of -420C/G gene between the cerebral infraction group and control group were not statistically significant. Samples of both groups accorded with the H-W test. The logistic regression analysis showed that sytolic pressure, fasting blood glucose, LDL-C, and TG were independent risk factors of cerebral infraction. Conclusion The polymorphism of locus -420 C/G of the resistin gene does not correlate to cerebral infraction