转录因子 C/EBPβ在子宫蜕膜化中的作用及机制研究进展
Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization

CCAAT 增强子结合蛋白 β（C/EBPβ）是 CCAAT 增强子结合蛋白家族的重要成员。C/EBPβ蛋白可通过其羧基端 bZIP 结构域调控 下游靶基因的转录活性，进而参与细胞的增殖、分化等生命活动。近期研究显示，C/EBPβ在子宫内膜基质细胞的蜕膜化过程中具有重要 的调控作用。该文就近年来 C/EBPβ在子宫内膜基质细胞蜕膜化中的作用及机制进行综述，旨在为临床蜕膜化障碍研究提供新的视角。
： CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization