%0 Journal Article
%T 转录因子 C/EBPβ在子宫蜕膜化中的作用及机制研究进展<br>Progress on roles and mechanisms of CCAAT/enhancer binding protein β in endometrium decidualization
%A 狄芳芳
%A 刘建胜
%A 李尚
%A 杜艳芝&lt
%A br&gt
%A DI Fang-fang
%A LIU Jian-sheng
%A LI Shang
%A DU Yan-zhi
%J 上海交通大学学报（医学版）
%D 2017
%R 10.3969/j.issn.1674-8115.2017.06.026
%X CCAAT 增强子结合蛋白 β（C/EBPβ）是 CCAAT 增强子结合蛋白家族的重要成员。C/EBPβ蛋白可通过其羧基端 bZIP 结构域调控 下游靶基因的转录活性，进而参与细胞的增殖、分化等生命活动。近期研究显示，C/EBPβ在子宫内膜基质细胞的蜕膜化过程中具有重要 的调控作用。该文就近年来 C/EBPβ在子宫内膜基质细胞蜕膜化中的作用及机制进行综述，旨在为临床蜕膜化障碍研究提供新的视角。<br>： CCAAT/enhancer binding protein β (C/EBPβ) is a critical member of C/EBP family. C/EBPβ, based on the leucine zipper located in C terminal of the protein, can regulate transcriptional activities of downstream target genes involved in diverse cellular processes, such as proliferation and differentiation. Recently published studies have identified that C/EBPβ is essential in the decidualization of endometrial stromal cells. This review summarizes the roles and mechanisms of C/EBPβ during the courses of decidualization, which is aimed at providing novel insights for dysfunctional decidualization
%K &ensp
%K CCAAT 增强子结合蛋白 &beta
%K 子宫内膜基质细胞
%K 蜕膜化
%K 增殖
%K 分化
%K 细胞周期
%K &lt
%K br&gt
%K CCAAT/enhancer binding protein β
%K endometrial stromal cell
%K decidualization
%K proliferation
%K differentiation
%K cell cycle
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11590.shtml