Rho/Rock信号通路与肺纤维化相关性的研究进展
Research progresses of the correlation between Rho/Rock signaling pathway and pulmonary fibrosis

Rho/Rock信号通路是调控细胞增殖和组织分化的重要信号通路，也是调节干细胞自我更新过程的信号转导通路。在各种炎症因子的刺激下，通过激酶级联反应，Rho/Rock通路参与了细胞的收缩、趋化、黏附和浸润等生物学行为。Rho/Rock信号转导通路与肺纤维化密切相关，深入了解Rho/Rock通路在肺纤维化中的作用及其机制，有可能为肺纤维化的防治找到新的突破点。
： Rho/Rock signaling pathway is a key signaling pathway regulating cell proliferation and tissue differentiation, as well as a signal transduction pathway moderating stem cell self-renewal process. Under the stimulation of a various inflammatory cytokines, Rho/Rock pathway is involved in biological behaviors such as cell contraction, chemotaxis, adhesion, and invasion via kinase cascade. Rho/Rock signaling transduction pathway is closely related to pulmonary fibrosis. Therefore, deep understanding of the effects and mechanisms of Rho/Rock pathway in pulmonary fibrosis may reveal novel breaking points for prevention and treatment of pulmonary fibrosis