%0 Journal Article
%T Rho/Rock信号通路与肺纤维化相关性的研究进展<br>Research progresses of the correlation between Rho/Rock signaling pathway and pulmonary fibrosis
%A 漆秀洁
%A 李静
%A 谭利平
%A 许峰
%A 方芳&lt
%A br&gt
%A QI Xiu-jie
%A LI Jing
%A TAN Li-ping
%A XU Feng
%A FANG Fang
%J 上海交通大学学报（医学版）
%D 2016
%R 10.3969/j.issn.1674-8115.2016.10.028
%X Rho/Rock信号通路是调控细胞增殖和组织分化的重要信号通路，也是调节干细胞自我更新过程的信号转导通路。在各种炎症因子的刺激下，通过激酶级联反应，Rho/Rock通路参与了细胞的收缩、趋化、黏附和浸润等生物学行为。Rho/Rock信号转导通路与肺纤维化密切相关，深入了解Rho/Rock通路在肺纤维化中的作用及其机制，有可能为肺纤维化的防治找到新的突破点。<br>： Rho/Rock signaling pathway is a key signaling pathway regulating cell proliferation and tissue differentiation, as well as a signal transduction pathway moderating stem cell self-renewal process. Under the stimulation of a various inflammatory cytokines, Rho/Rock pathway is involved in biological behaviors such as cell contraction, chemotaxis, adhesion, and invasion via kinase cascade. Rho/Rock signaling transduction pathway is closely related to pulmonary fibrosis. Therefore, deep understanding of the effects and mechanisms of Rho/Rock pathway in pulmonary fibrosis may reveal novel breaking points for prevention and treatment of pulmonary fibrosis
%K Rho
%K Rock
%K 信号通路
%K 肺纤维化
%K &lt
%K br&gt
%K Rho
%K Rock
%K pathway
%K pulmonary fibrosis
%U http://xuebao.shsmu.edu.cn/CN/abstract/abstract11334.shtml