Background:Hyoscinebutylbromide
(Buscopan) is being used as an agent for reducing the duration of labour. There
are however conflicting results on the effect of this agent on cervical
dilation.Materials and Methods:This was an open label clinical trial of one hundred
and thirty two (132) pregnant women in labour. Women were grouped to receive
either 20mg of hyoscine butyl bromide intramuscularly at the onset of active phase
labour or placebo “Normal saline”. The main outcome measure was to compare the
duration of first stage labour in the study and control groups as well as
feto-maternal outcomes. Relevant data were collected using a proforma. The data
were analysed using Statistical Package for Social Sciences (SPSS) version
20. Results: A total of 132 were randomised and 123 yielded for
analysis. Of these 59 received hyoscine butyl bromide and 64 received placebo.
There was no significant difference in the mean duration of active labour to
second stage between the drug and placebo arms (312.5 versus 305.3 minutes,
respectively,
References
[1]
Ijaiya, M.A., Aboyeji, A.P., Fakeye, O.O., Balogun, O.R., Nwachukwu, D.C. and Abiodun, M.O. (2009) Pattern of Cervical Dilatation among Parturient in Ilorin, Nigeria. Annals of African Medicine, 8, 181-184.
[2]
Melah, G.S., El-Nafaty, A.U., Massa, A.A. and Audu, B.M. (2003) Obstructed Labour: A Public Health Problem in Gombe State, Nigeria. Journal of Obstetrics and Gynaecology, 23, 369-373. https://doi.org/10.1080/01443610310001119510
[3]
Campbell, S. and Lee, C. (2005) Labour. In: Lee, C., Ed., Obstetrics by Ten Teachers, 17th Edition, Hodder Arnold, London, 101-139.
[4]
Ande, A.B.A. and Okpere, E.E. (2004) Prolonged Labour. In: Okpere, E., Ed., Clinical Obstetrics, Revised Edition, Uniben Press, Benin, 222-223.
[5]
Orhue, A.A. and Otubu, J.A. (2006) Prolonged Labour. In: Agboola, A., Ed., Text Book of Obstetrics and Gynaecology for Medical Students, 2nd Edition, Heinemann Educational Books, Ibadan, 439-441.
[6]
Randhawa, I., Gupta, K.B. and Kanwal, M. (1991) A Study of Prolonged Labour. Journal of the Indian Medical Association, 89, 161-163.
[7]
Hendricks, C.H., Brenner, W.E. and Kraus, G. (1970) Normal Cervical Dilatation Pattern in Late Pregnancy and Labour. American Journal of Obstetrics & Gynecology, 106, 1065-1082. https://doi.org/10.1016/S0002-9378(16)34092-3
[8]
O’Driscoll, K., Stronge, J.M. and Minogue, M. (1973) Active Management of Labour. BMJ, 3, 135-137. https://doi.org/10.1136/bmj.3.5872.135
[9]
Ekele, B.A. and Amayo, O. (2004) Physiology of Labour. In: Okpere, E., Ed., Clinical Obstetrics, Revised Edition. Uniben Press, Benin, 202-208.
[10]
Hudesek, R., Nagy, J. and Unzeetig, V. (1997) The Effect of Spasmolytics on Dilatation of the Uterine Cervix. Ceska Gynecologie, 62, 11-14.
https://europepmc.org/abstract/med/9410414
[11]
Qahtani, N.H. and Hajeri, F.A. (2011) The Effect of Hyoscine Butyl Bromide in Shortening the First Stage of Labour; A Double Blind, Randomised Controlled, Clinical Trial. Therapeutics Clinical Risk Management, 7, 495-500.
https://doi.org/10.2147/TCRM.S16415
[12]
Sadler, L.C., Davidson, T. and McCowan, L.M. (2000) A Randomised Controlled Trial and Meta-Analysis of Active Management of Labour. BJOG, 7, 909-915.
https://doi.org/10.1111/j.1471-0528.2000.tb11091.x
[13]
Rohwer, A.C., Khondowe, O. and Young, T. (2013) Antispamodics for Labour. Cochrane Databases of Systematic Reviews, No. 6.
[14]
Ryan, J. and Heitmann, D.O. (2013) Anatomy of the Female Reproductive System. In: Decherney, A.N., Nathan, L., Laufer, N. and Roman, A.S., Eds., Current Obstetrics and Gynaecologic Diagnosis and Treatment, 11th Edition, MC Graw Hill Publishers, New York, 1-37.
[15]
Campell, M.J. and Machin, D.C. (1990) Comparison of Proportion. In: Medical Statistics, a Common Sense Approach, John Wiley & Sons Ltd., West Sussex, 148.
[16]
Sreelatha, S., Vedavathy, N., Gayathri, C. and Renuka, R. (2015) A Study of the Effect of Hyoscinebutylbromide on the Duration of Labour. World Journal of Pharmaceutical Research, 10, 2485-2491.
[17]
Jenkin, G. and Young, I. (2004) Mechanisms Responsible for Parturition; The Use of Experimental Models. Animal Reproduction Science, 82, 567-581.
https://doi.org/10.1016/j.anireprosci.2004.05.010
[18]
Al Dohami, H.S. and Al Matari, F.I. (2002) Is Buscopan (Hyoscine N-Butylbromide) Effective in Shortening Labour? 12th Annual General Meeting of the Saudi Obstetrics and Gynaecology Society.
[19]
Samuels, L.A., Christie, L., Roberts, G.B., Fletcher, H. and Frederick, J. (2007) The Effect of Hyoscinebutylbromide on the 1st Stage of Labour in Term Pregnancies. BJOG, 12, 1542-1544. https://doi.org/10.1111/j.1471-0528.2007.01497.x
[20]
Mukaindo, A.M. (2013) The Efficacy of Intravenous Hyoscine Butyl Bromide (Buscopan) for the Acceleration of Labour in First Time. Paturients a Randomised Double Blind, Placebo Controlled Trial East Africa FHS MC Obstetrics and Gynaecology.
