Objective:Toevaluate the association between hypertension and β-blocker (BB) use and antepartum depression risk. Patients and Methods: We conducted a retrospective cohort study of women who delivered within our integrated
health system between 2009 and 2015, and completed an Edinburgh Postnatal
Depression Scale (EPDS) during pregnancy. Increased depression risk was defined
as EPDS score ≥ 10, or an affirmative answer to question ten, endorsing
self-harm. Antepartum hypertension was determined by blood pressure
measurements andprovider ICD-9 codes. Regression analyses examined the independent
associations ofBB use and hypertension on antepartum depression risk. Results: Of
9192 deliveries during the study time frame, 5% were hypertensive. Within the
hypertensive group, 103 (22%) used a single agent BB (BB Group), 325 (68%)
required no antihypertensive medication (No-Med Group), and 48 (10%) useda
non-BB single agent or multi-agent therapy (All-Other Group). After adjusting
for covariates, compared to normotensive pregnancies, antepartum hypertension
was significantly associated with both EPDS score ≥ 10 (adjusted odds ratio[aOR]
1.61, 95% confidence interval [CI]
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