%0 Journal Article
%T Association of Hypertension and <i>¦Â</i>-Blocker Use with Depression during Pregnancy
%A Alicia M. McCarthy
%A Ying Zhou
%A Marci Adams
%A Rita Elue
%A Nicole Diaz
%A Beth A. Plunkett
%J Open Journal of Obstetrics and Gynecology
%P 925-935
%@ 2160-8806
%D 2018
%I Scientific Research Publishing
%R 10.4236/ojog.2018.811094
%X <strong>Objective:</strong> <span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">To</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">evaluate the association between hypertension and </span><i><span style=\"font-family:Verdana;\">¦Â</span></i><span style=\"font-family:Verdana;\">-blocker (BB) use and antepartum depression risk. </span><b><span style=\"font-family:Verdana;\">Patients and Methods:</span></b><span style=\"font-family:Verdana;\"> We conducted a retrospective cohort study of women who delivered within our integrated
health system between 2009 and 2015, and completed an Edinburgh Postnatal
Depression Scale (EPDS) during pregnancy. Increased depression risk was defined
as EPDS score ¡Ý 10, or an affirmative answer to question ten, endorsing
self-harm. Antepartum hypertension was determined by blood pressure
measurements and</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">provider ICD-9 codes. Regression analyses examined the independent
associations of</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">BB use and hypertension on antepartum depression risk. </span><b><span style=\"font-family:Verdana;\">Results:</span></b><span style=\"font-family:Verdana;\"> Of
9192 deliveries during the study time frame, 5% were hypertensive. Within the
hypertensive group, 103 (22%) used a single agent BB (BB Group), 325 (68%)
required no antihypertensive medication (No-Med Group), and 48 (10%) used</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">a
non-BB single agent or multi-agent therapy (All-Other Group). After adjusting
for covariates, compared to normotensive pregnancies, antepartum hypertension
was significantly associated with both EPDS score ¡Ý 10 (adjusted odds ratio</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">[aOR]
1.61, 95% confidence interval [CI]
%K &lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K -Blocker
%K Depression
%K Hypertension
%K Labetalol
%K Pregnancy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=87094