Background: To explore the therapeutic effect of Tongxinluo
capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. Methods: Fifty-six patients with Syndrome X and Affective Disorder were randomly divided
into a Tongxinluo capsule group and a placebo control group. The duration of
treatment was 12 weeks. A 6-minute walking test, exercise load electrocardiogram
and clinical symptom assessment were performed before and after treatment.
After 12 weeks of treatment, the scores of the Self-Rating Anxiety Scale (SAS)
and Self-Rating Depression Scale (SDS) were repeated. The levels of serum endothelin-1
(ET-1) and nitric oxide (NO) were measured before and after treatment. Results: Compared with the placebo control group, the Tongxinluo group SAS and SDS
scores were lower than those before treatment (all P < 0.01), and the 6-minute walking distance increased
significantly (P < 0.01). Clinical
symptoms were significantly improved. The exercise test results suggested that,
while improved, there was no significant difference (P > 0.05) when compared to before treatment. In the Tongxinluo
treatment group, the levels of plasma endothelin-1 decreased significantly (P < 0.01) and nitric oxide levels
were significantly increased (P < 0.01),
with a significant difference when compared to the control group (P < 0.01). Conclusions: The
Tongxinluo capsule can improve the Affective Disorder of Syndrome X, reduce the
degree of anxiety and depression, increase exercise tolerance, reduce clinical
symptoms, and improve vascular endothelial
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