%0 Journal Article
%T Effect of Tongxinluo Capsule on Patients with Syndrome X and Affective Disorder
%A Xiaolei Lv
%A Zhiqiang Zhao
%A Jieyuan Feng
%A Jianzhong Zhu
%J Chinese Medicine
%P 55-62
%@ 2151-1926
%D 2018
%I Scientific Research Publishing
%R 10.4236/cm.2018.92004
%X <p style=\"text-align:justify;\">
	<b><span style=\"font-family:Verdana;\">Background: </span></b><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">To explore the therapeutic effect of Tongxinluo
capsule (Tongxinluo) on patients with Syndrome X and Affective Disorder. </span><b><span style=\"font-family:Verdana;\">Methods: </span></b><span style=\"font-family:Verdana;\">Fifty-six patients with Syndrome X and Affective Disorder were randomly divided
into a Tongxinluo capsule group and a placebo control group. The duration of
treatment was 12 weeks. A 6-minute walking test, exercise load electrocardiogram
and clinical symptom assessment were performed before and after treatment.
After 12 weeks of treatment, the scores of the Self-Rating Anxiety Scale (SAS)
and Self-Rating Depression Scale (SDS) were repeated. The levels of serum endothelin-1
(ET-1) and nitric oxide (NO) were measured before and after treatment. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">Compared with the placebo control group, the Tongxinluo group SAS and SDS
scores were lower than those before treatment (all </span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&lt; 0.01), and the 6-minute walking distance increased
significantly (</span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&lt; 0.01). Clinical
symptoms were significantly improved. The exercise test results suggested that,
while improved, there was no significant difference (</span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&gt; 0.05) when compared to before treatment. In the Tongxinluo
treatment group, the levels of plasma endothelin-1 decreased significantly (</span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&lt; 0.01) and nitric oxide levels
were significantly increased (</span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&lt; 0.01),
with a significant difference when compared to the control group (</span><i><span style=\"font-family:Verdana;\">P </span></i><span style=\"font-family:Verdana;\">&lt; 0.01). </span><b><span style=\"font-family:Verdana;\">Conclusions: </span></b><span style=\"font-family:Verdana;\">The
Tongxinluo capsule can improve the Affective Disorder of Syndrome X, reduce the
degree of anxiety and depression, increase exercise tolerance, reduce clinical
symptoms, and improve vascular endothelial
%K Syndrome X
%K Affective Disorder
%K 6-Minute Walking Test
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=85181