Inter-Fraction and Intra-Fraction Variation in the Absorbed-Dose Delivery during Interstitial High Dose Rate Brachytherapy—A Study Using MicroMOSFET In-Vivo Dosimeter
Background: The
delivered dose has to be checked and verified with planned dose since precise
and accurate dose delivery is essential in Brachytherapy. Sources of
uncertainty during Brachytherapy are intra-fraction, inter-fraction and
inter-application variations. In-vivo dosimetry is the direct method to monitor
the radiation dose delivered to a patient during radiotherapy. In this study, assessment
of the inter-fraction and intra-fraction variations in the interstitial
Brachytherapy was done with microMOSFET. Aim: To analyze the inter-fraction
variations in dose delivery during interstitial HDR Brachytherapy and to
compare the measured point dose with the TPS-calculated point dose, intra-fraction variation, using the
microMOSFET in-vivo dosimeter.Materials and
Methods: From May 2014 to
February 2016, 22 patients with Head and
Neck cancers and 8 patients with Soft-Tissue Sarcomas (STS) were selected
for this study. All these patients underwent CT imaging more than 24 hours
after the application. Brachyvision 3DTPS and GammaMed Plus iX HDR unit were used for treatments. MicroMOSFET in-vivo dosimeter after calibration was used for the
measurements of dose inside the treated volume. Intra &
References
[1]
Nath, R., Rivard, M.J., De Werd, L.A., et al. (2016) Guidelines by the AAPM and GEC-ESTRO on the Use of Innovative Brachytherapy Devices and Applications: Report of Task Group 167. Medical Physics, 43, 3178-3205. https://doi.org/10.1118/1.4951734
[2]
Takácsi-Nagy, Z., Martínez-Mongue, R., Mazeron, J.J., Anker, C.J. and Harrison, L.B. (2016) American Brachytherapy Society Task Group Report: Combined External Beam Irradiation and Interstitial Brachytherapy for Base of Tongue Tumors and Other Head and Neck Sites in the Era of New Technologies. Brachytherapy, 16, 44-58. https://doi.org/10.1016/j.brachy.2016.07.005
[3]
Palmer, A., Bradley, D. and Nisbet, A. (2012) Physics-Aspects of Dose Accuracy in High Dose Rate (HDR) Brachytherapy: Source Dosimetry, Treatment Planning, Equipment Performance and In Vivo Verification Techniques. Journal of Contemporary Brachytherapy, 4, 81. https://doi.org/10.5114/jcb.2012.29364
[4]
Potter, R., Kisistis, C. and Erickson, B. (2013) Prescribing, Recording and Reporting Brachytherapy for Cancer of the Cervix. J ICRU Report, 13, 1-2.
[5]
York, E. (2005) Diode In Vivo Dosimetry for Patients Receiving External Beam Radiation Therapy: Report of the American Association of Physicists in Medicine (AAPM) Task Group 62. Medical Physics Publishing, Madison.
[6]
Tanderup, K., Beddar, S., Andersen, C.E., Kertzscher, G. and Cygler, J.E. (2013) In Vivo Dosimetry in Brachytherapy. Medical Physics, 40, Article Number: 070902. https://doi.org/10.1118/1.4810943
[7]
Lambert, J., Nakano, T., Law, S., Elsey, J., McKenzie, D.R. and Suchowerska, N. (2007) In Vivo Dosimeters for HDR Brachytherapy: A Comparison of a Diamond Detector, MOSFET, TLD, and Scintillation Detector. Medical Physics, 34, 1759-1765. https://doi.org/10.1118/1.2727248
[8]
Tarr, N.G., Mackay, G.F., Shortt, K. and Thomson, I. (1997) A Floating Gate MOSFET Dosimeter Requiring no External Bias Supply. Fourth European Conference on Radiation and Its Effects on Components and Systems, 1997, Cannes, 15-19 September 1997, 277-281.
[9]
Gopiraj, A., Billimagga, R.S. and Ramasubramanian, V. (2008) Performance Characteristics and Commissioning of MOSFET as an In-Vivo Dosimeter for High Energy Photon External Beam Radiation Therapy. Reports of Practical Oncology and Radiotherapy, 13, 114-125. https://doi.org/10.1016/S1507-1367(10)60001-6
[10]
Ramaseshan, R., Kohli, K.S., Zhang, T.J., et al. (2004) Performance Characteristics of a microMOSFET as an In Vivo Dosimeter in Radiation Therapy. Physics in Medicine and Biology, 49, 4031. https://doi.org/10.1088/0031-9155/49/17/014
[11]
Kinhikar, R.A., Sharma, P.K., Tambe, C.M. and Deshpande, D.D. (2006) Dosimetric Evaluation of a New One Dose MOSFET for Ir-192 Energy. Physics in Medicine & Biology, 51, 1261. https://doi.org/10.1088/0031-9155/51/5/015
[12]
Zilio, V.O., Joneja, O.P., Popowski, Y., Rosenfeld, A. and Chawla, R. (2006) Absolute Depth-Dose-Rate Measurements for an Ir192 HDR Brachytherapy Source in Water using MOSFET Detectors. Medical Physics, 33, 1532-1539. https://doi.org/10.1118/1.2198168
[13]
Rey, F., Chang, C., Mesina, C., Dixit, N., Teo, B.K. and Lin, L.L. (2013) Dosimetric Impact of Interfraction Catheter Movement and Organ Motion on MRI/CT Guided HDR Interstitial Brachytherapy for Gynecologic Cancer. Radiotherapy and Oncology, 107, 112-116. https://doi.org/10.1016/j.radonc.2012.12.013
[14]
Kandasamy, S., Reddy, K.S., Nagarajan, V., Vedasoundaram, P. and Karunanidhi, G. (2013) Dosimetric Impact of Inter-Fraction Variation in Interstitial HDR Brachytherapy. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 2, 111. https://doi.org/10.4236/ijmpcero.2013.24015
[15]
Takenaka, T., Yoshida, K., Ueda, M., et al. (2012) Assessment of Daily Needle Applicator Displacement during High-Dose-Rate Interstitial Brachytherapy for Prostate Cancer using Daily CT Examinations. Journal of Radiation Research, 53, 469-474.
[16]
Onoe, T., Nose, T., Yamashita, H., Yoshioka, M., Toshiyasu, T., Kozuka, T., Oguchi, M. and Nakagawa, K. (2013) High-Dose-Rate Interstitial Brachytherapy for Gynecologic Malignancies—Dosimetric Changes during Treatment Period. Journal of Radiation Research, 54, 663-670. https://doi.org/10.1093/jrr/rrs130
[17]
Qi, Z.Y., Deng, X.W., Cao, X.P., Huang, S.M., Lerch, M. and Rosenfeld, A. (2012) A Real-Time in Vivo Dosimetric Verification Method for High-Dose Rate Intracavitary Brachytherapy of Nasopharyngeal Carcinoma. Medical Physics, 39, 6757-6763. https://doi.org/10.1118/1.4758067
[18]
Velmurugan, T., Sukumar, P., Krishnappan, C. and Boopathy, R. (2010) Study of Dosimetric Variation Due to Interfraction Organ Movement in High Dose Rate Interstital (MUPIT) Brachytherapy for Gynecologic Malignancies. Polish Journal of Medical Physics and Engineering, 16, 85-95.
