Background: The
Mediterranean Diet (MD) has been linked to a reduced risk of developing
degenerative diseases, including atherosclerosis, heart stroke, diabetes,
arthritis and cancer. However, only a few scientific investigations have
attempted to validate this impression. The ingredients of the MD include
significant amounts of omega (ω3,?ω6,
and?ω9) unsaturated fatty
acids (UFAs). A few studies of these UFAs in the prevention or treatment of
arthritis have yielded controversial results, but a general belief regarding
their beneficial effects has prevailed. Objective: To investigate the effects
of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid
(AA), and Oleic Acid (OA) (ω3,?ω6,
and?ω9, respectively), in
the development of arthritis using a murine model of Collagen-Induced Arthritis
(CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII)
and were subsequently treated with?ω-UFAs
for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory
agent. The effect of the treatments was evaluated through several parameters:
inflammation indices, antibody levels, cell prolifera- tion, and
histopathological findings. Results and Conclusion: The
References
[1]
Asquith, D.L., Miller, A.M., McInnes, I.B. and Liew, F.Y. (2009) Animal Models of Rheumatoid Arthritis. European Journal of Immunology, 39, 2040-2044. http://dx.doi.org/10.1002/eji.200939578
[2]
Brand, D.D., Kang, A.H. and Rosloniec, E.F. (2003) Immunopathogenesis of Collagen Arthritis. Seminars in Immunopathology, 25, 3-18. http://dx.doi.org/10.1007/s00281-003-0127-1
[3]
Rosloniec, E.F., Cremer, M., Kang, A.H., Myers, L.K. and Brand, D.D. (2010) Collagen-Induced Arthritis. Current Protocols in Immunology, 15, 1-25. http://dx.doi.org/10.1002/0471142735.im1505s89
[4]
Meier, F.M.P., Frerix, M., Hermann, W. and Müller-Ladner, U. (2013) Current Immunotherapy in Rheumatoid Arthritis. Immunotherapy, 5, 955-974. http://dx.doi.org/10.2217/imt.13.94
[5]
Lopez, M.A., Siddhanamatha, H.R., Shea, B., Tugwell, P., Wells, G.A. and Suarez, M.E. (2014) Methotrexate for Treating Rheumatoid Arthritis. Cochrane Database of Systematic Reviews, 10, 6.
[6]
Visser, K. and van der Heijde, D. (2009) Optimal Dosage and Route of Administration of Methotrexate in Rheumatoid Arthritis: A Systematic Review of the Literature. Annals of the Rheumatic Diseases, 68, 1094-1099. http://dx.doi.org/10.1136/ard.2008.092668
[7]
Bonilla-Hernán, M.G., Miranda-Carús, M.E. and Martin-Mola, E. (2011) New Drugs beyond Biologics in Rheumatoid Arthritis: The Kinase Inhibitors. Rheumatology, 50, 1542-1550. http://dx.doi.org/10.1093/rheumatology/ker192
[8]
Gardener, H., Wright, C.B., Cabral, D., Scarmeas, N., Gu, Y., Cheung, K., Elkind, M.S., Sacco, R.L. and Rundek, T. (2014) Mediterranean Diet and Carotid Atherosclerosis in the Northern Manhattan Study. Atherosclerosis, 2, 303-310. http://dx.doi.org/10.1016/j.atherosclerosis.2014.03.011
[9]
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., Lamuela-Raventos, R.M., Serra-Majem, L., Pintó, X., Basora, J., Mu?oz, M.A., Sorlí, J.V., Martínez, J.A. and Martínez-González, M.A. (2013) Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. New England Journal of Medicine, 368, 1279-1290. http://dx.doi.org/10.1056/NEJMoa1200303
[10]
Lee, Y.H., Bae, S.C. and Song, G.G. (2012) Omega-3 Polyunsaturated Fatty Acids and the Treatment of Rheumatoid Arthritis: A Meta-Analysis. Archives of Medical Research, 43, 356-362. http://dx.doi.org/10.1016/j.arcmed.2012.06.011
[11]
Barrea, L., Balato, N., DiSomma, C., Macchia, P.E., Napolitano, M., Savanelli, M.C., Esposito, K., Colao, A. and Savastano, S. (2015) Nutrition and Psoriasis: Is There Any Association between the Severity of the Disease and Adherence to the Mediterranean Diet? Journal of Translational Medicine, 13, 18. http://dx.doi.org/10.1186/s12967-014-0372-1
[12]
Salas-Salvadó, J., Bulló, M., Babio, N., Martínez-González, M.á., Ibarrola-Jurado, N., Basora, J., Estruch, R., Covas, M.I., Corella, D., Arós, F., Ruiz-Gutiérrez, V. and Ros, E. (2011) Reduction in the Incidence of Type Diabetes with the Mediterranean Diet. Diabetes Care, 34, 14-19. http://dx.doi.org/10.2337/dc10-1288
[13]
Fiala, M. (2015) Curcumin and Omega-3 Fatty Acids Enhance NK Cell-Induced Apoptosis of Pancreatic Cancer Cells but Curcumin Inhibits Interferon-γ Production: Benefits of Omega-3 with Curcumin against Cancer. Molecules, 20, 3020-3026. http://dx.doi.org/10.3390/molecules20023020
[14]
Castelló, A., Pollán, M., Buijsse, A., Ruiz, A., Casas, A., Baena-Ca?ada, J.E., Lope, V., Antolín, S., Ramos, M., Mu?oz, M., Lluch, A., de Juan-Ferré, A., Jara, C., Jimeno, M.A., Rosado, P., Díaz, E., Guillem, V., Carrasco, E., Pérez-Gómez, B., Vioque, J., Boeing, H. and Martín, M. (2014) Spanish Mediterranean Diet and Other Dietary Patterns and Breast Cancer Risk: Case-Control EpiGEICAM Study. British Journal of Cancer, 111, 1454-1462. http://dx.doi.org/10.1038/bjc.2014.434
[15]
Gheita, T., Kamel, S., Helmy, N., El-Laithy, N. and Monir, A. (2012) Omega-3 Fatty Acids in Juvenile Idiopathic Arthritis: Effect on Cytokines (IL-1 and TNF-α), Disease Activity and Response Criteria. Clinical Rheumatology, 31, 363-366. http://dx.doi.org/10.1007/s10067-011-1848-5
[16]
Olson, M.V., Liu, Y.C., Dangi, B., Paul Zimmer, J., Salem Jr., N. and Nauroth, J.M. (2013) Docosahexaenoic Acid Reduces Inflammation and Joint Destruction in Mice with Collagen-Induced Arthritis. Inflammation Research, 62, 1003-1013. http://dx.doi.org/10.1007/s00011-013-0658-4
[17]
Torres-Guzman, A.M., Morado-Urbina, C.E., Alvarado-Vazquez, P.A., Acosta-Gonzalez, R.I., Chávez-Pi?a, A.E., Montiel-Ruiz, R.M. and Jimenez-Andrade, J.M. (2014) Chronic Oral or Intra-Articular Administration of Docosahexaenoic Acid Reduces Nociception and Knee Edema and Improves Functional Outcomes in a Mouse Model of Complete Freund’s Adjuvant-Induced Knee Arthritis. Arthritis Research & Therapy, 10, R64.
[18]
Inglis, J., Simelyte, E., McCann, F., Criado, G. and Williams, R. (2008) Protocol for the Induction of Arthritis in C57BL/6 Mice. Nature Protocols, 4, 612-618. http://dx.doi.org/10.1038/nprot.2008.19
[19]
Bevaart, L., Vervoordeldonk, M.J. and Tak, P.P. (2010) Collagen Induced Arthritis in Mice. In: Proetzel, G. and Wiles, M.V., Eds., Mouse Models for Drug Discovery, Methods in Molecular Biology, Humana Press, New York City, 181- 192. http://dx.doi.org/10.1007/978-1-60761-058-8_11
[20]
Rosillo, M.A., Alcaraz, M.J., Sánchez-Hidalgo, M., Fernández-Bola?os, J.G., Alarcón-de-la-Lastra, C. and Ferrándiz, M.L. (2014) Anti-Inflammatory and Joint Protective Effects of Extra-Virgin Olive-Oil Polyphenol Extract in Experimental Arthritis. The Journal of Nutritional Biochemistry, 12, 1275-1281. http://dx.doi.org/10.1016/j.jnutbio.2014.07.006
[21]
Impellizzeri, D., Esposito, E., Mazzon, E., Paterniti, I., DiPaola, R., Morittu, V.M., Procopio, A., Britti, D. and Cuzzocrea, S. (2011) Oleuropein Aglycone, an Olive Oil Compound, Ameliorates Development of Arthritis Caused by Injection of Collagen Type II in Mice. Journal of Pharmacology and Experimental Therapeutics, 339, 859-869. http://dx.doi.org/10.1124/jpet.111.182808
[22]
Singer, P., Shapiro, H., Theilla, T., Anbar, R., Singer, J. and Cohen, J. (2008) Anti-Inflammatory Properties of Omega- 3 Fatty Acids in Critical Illness: Novel Mechanisms and an Integrative Perspective. Intensive Care Medicine, 34, 1580- 1592. http://dx.doi.org/10.1007/s00134-008-1142-4
[23]
Yaqoob, P., Newsholme, E.A. and Calder, P.C. (1994) The Effect of Dietary Lipid Manipulation on Rat Lymphocyte Subsets and Proliferation. Immunology, 82, 603-6010.
Gorjao, R., Cury-Boaventura, M.A., Martins, T. and Curi, R. (2007) Regulation of Human Lymphocyte Proliferation by Fatty Acids. Cell Biochemistry and Function, 25, 305-315. http://dx.doi.org/10.1002/cbf.1388
[26]
Kim, H.J., Vosseler, C.A., Weber, P.C. and Erl, W. (2005) Docosahexaenoic Acid Induces Apoptosis in Proliferating Human Endothelial Cells. Journal of Cellular Physiology, 204, 881-888. http://dx.doi.org/10.1002/jcp.20351
[27]
Gorjao, R., Cury-Boaventura, M.A., Kanunfre, C.C., Martins, T. and Curi, R. (2006) Mechanisms Involved in Jurkat Cell Death Induced by Oleic and Linoleic Acids. Clinical Nutrition, 25, 1004-1014. http://dx.doi.org/10.1016/j.clnu.2006.05.008
[28]
Hofmanová, J., Vaculová, A., Lojek, A. and Kozubík, A. (2005) Interaction of Polyunsaturated Fatty Acids and Sodium Butyrate during Apoptosis in HT-29 Human Colon Adenocarcinoma Cells. European Journal of Nutrition, 44, 40-51. http://dx.doi.org/10.1007/s00394-004-0490-2