Background: The
Mediterranean Diet (MD) has been linked to a reduced risk of developing
degenerative diseases, including atherosclerosis, heart stroke, diabetes,
arthritis and cancer. However, only a few scientific investigations have
attempted to validate this impression. The ingredients of the MD include
significant amounts of omega (ω3,？ω6,
and？ω9) unsaturated fatty
acids (UFAs). A few studies of these UFAs in the prevention or treatment of
arthritis have yielded controversial results, but a general belief regarding
their beneficial effects has prevailed. Objective: To investigate the effects
of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid
(AA), and Oleic Acid (OA) (ω3,？ω6,
and？ω9, respectively), in
the development of arthritis using a murine model of Collagen-Induced Arthritis
(CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII)
and were subsequently treated with？ω-UFAs
for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory
agent. The effect of the treatments was evaluated through several parameters:
inflammation indices, antibody levels, cell prolifera- tion, and
histopathological findings. Results and Conclusion: The
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