%0 Journal Article
%T Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse
%A Pamela Izaret P¨¦rez-Mart¨ªnez
%A V¨ªctor Gabriel Hern¨¢ndez
%A Oscar Rodr¨ªguez-Espinosa
%A Patricia Arce-Paredes
%A Oscar Rojas-Espinosa
%J Modern Research in Inflammation
%P 31-44
%@ 2169-9690
%D 2016
%I Scientific Research Publishing
%R 10.4236/mri.2016.53004
%X Background: The
Mediterranean Diet (MD) has been linked to a reduced risk of developing
degenerative diseases, including atherosclerosis, heart stroke, diabetes,
arthritis and cancer. However, only a few scientific investigations have
attempted to validate this impression. The ingredients of the MD include
significant amounts of omega (¦Ø3, ¦Ø6,
and ¦Ø9) unsaturated fatty
acids (UFAs). A few studies of these UFAs in the prevention or treatment of
arthritis have yielded controversial results, but a general belief regarding
their beneficial effects has prevailed. Objective: To investigate the effects
of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid
(AA), and Oleic Acid (OA) (¦Ø3, ¦Ø6,
and ¦Ø9, respectively), in
the development of arthritis using a murine model of Collagen-Induced Arthritis
(CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII)
and were subsequently treated with ¦Ø-UFAs
for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory
agent. The effect of the treatments was evaluated through several parameters:
inflammation indices, antibody levels, cell prolifera- tion, and
histopathological findings. Results and Conclusion: The
%K Collagen
%K CIA
%K DBA-1 Mice
%K Omega-UFAs
%K Dexamethasone
%K Anti-Inflammatory
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=69351