In
this study, we evaluated the anti-cancer property of five bark extracts and the
isolates from chloroform and ethyl acetate of Annickia chlorantha by the tetrazolium salt method (MTT method).
The anti-cancer activity was performed on human prostate cancer cell lines PC-3
and hormone-dependent breast cancer cell lines MCF-7. Results indicated that
the two isolates displayed interesting cytotoxicity towards MCF-7 cell lines
with CC50 of 3.84 CC50/mL and 4.87 CC50/mL for
chloroform and ethyl acetate respectively; while the total bark extracts showed
CC50 of 24.33 CC50/mL, 36.49 CC50/ mL and
73.52 CC50/mL for chloroform, ethyl
acetate and methanol extracts respectively. By the other hand on PC-3, the CC50 of the isolates were higher than the one on MCF-7, more than 10 CC50/mL
for both chloroform and ethyl acetate isolates and 49.14 CC50/mL,
77.33 CC50/mL, 89.38 CC50/mL and 92.37 CC50/mL,
respectively for chloroform, ethyl acetate and methanol soluble extracts. From
this study, we identified that the two isolates had anti-cancer properties
against MCF-7 cell lines.
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